在柠檬酸中添加壳聚糖配成的固化液与磷酸钙骨水泥(CPC)调和制备的骨修复材料具有类似口香糖的胶状特性,可应用于碎骨粘结,称之为磷酸钙骨粘合剂(CPCBA).本研究考察了柠檬酸的含量对抗压强度、固化时间、水化产物和粘结强度的影响,同时对该体系进行了初步的体外生物学评价.结果显示,加入柠檬酸可以缩短固化时间并且时间可以通过柠檬酸的含量进行调控,同时也改善了抗水性能.壳聚糖可以与骨水泥中的钙离子发生螯合作用,可以增加界面的粘结强度.小鼠原成骨细胞(MC3T3-E1)在其表面粘附良好,该体系骨水泥有望取代PMMA成为新的骨粘结剂.
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