在制备复合磷酸盐多孔陶瓷的基础上,采用稀浆料对其进行多次重复涂覆,通过扫描电镜(SEM)、排水法和体外细胞实验等对比了多次涂覆前后样品的孔隙特征,表面结构和细胞相容性.结果发现,随着涂覆次数的增加,样品的孔壁厚度有所增加,孔隙率呈下降趋势.不过经过3次涂覆后,样品孔隙形貌并没有太大的变化,孔隙率仍大于80％.同时多次涂覆使陶瓷表面增加了大量的1～2 μm的微孔结构,体外实验结果显示,这种结构有利于兔骨髓基质干细胞的粘附、铺展和生长.研究表明,多次涂覆(特别是3次涂覆)在不明显改变多孔陶瓷孔隙特征的前提下,改变了表面微观结构,提高了细胞相容性.
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