铜作为人体含量第二的必需微量元素，不仅在人体新陈代谢过程中起着重要作用，同时还具有抗菌性。因此，合成掺铜羟基磷灰石(Cu-HA)可望获得具有优良生物学性能兼具抗菌性能的生物陶瓷。本研究以硝酸钙、硝酸铜和磷酸氢二钠为原料，采用水热合成法制备掺铜HA。采用扫描电镜、透射电镜、X射线衍射、红外和原子吸收光谱对样品进行表征。结果表明：溶液体系中加入Cu2+后， Cu取代部分Ca进入HA晶格，使其形貌由带状转变为花瓣状微球；但Cu的掺入，并不影响HA晶体结构；当溶液中Cu/(Cu+Ca)摩尔比高于0.05时， HA产物的热稳定性下降。
As the second essential trace element in human body, copper plays vital roles in metabolism and antim-icrobial. Therefore, synthesis of copper-substituted hydroxyapatite (Cu-HA) is expected to create bioceramics with improved biological and antimicrobial properties. In this study, Cu-HA was prepared by hydrothermal reactions using Ca(NO3)2·4H2O, Cu(NO3)2·3H2O and Na2HPO4·12H2O. Products were characterized by scanning electron microscope, transmission electron microscope, X-ray diffraction, Fourier transform infrared spectroscope and atomic absorption spectrometry. Results show that copper is incorporated into the HA crystals. Correspondingly, the products retain HA structure but their morphologies transform from ribbons to flower-like microspheres. Moreover, when Cu/(Cu+Ca) (molar ratio) of the reaction solution is greater than 0.05, the thermal stability of the HA product is decreased.
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