以三苯基膦为母体骨架,设计合成了在苯环上连有环状仲胺取代基的五种新型P,N-配体(L1～L5),利用核磁共振谱(1H,13C,31p)、红外光谱、高分辨质谱和X射线单晶衍射等对配体进行了表征,并将它们应用于Pd催化的C-N键偶联反应中.结果表明,三(2-吗啉基苯基)膦(L5)与三(二亚苄基丙酮)二钯(Pd2(dba)3)组成的体系可有效催化芳基溴代物与仲胺的偶联反应,当以Pd2(dba)3(1 mol％)为催化剂前体、L5(6 mol％)为配体、叔丁醇钠(1.4 mmol)为碱、甲苯为溶剂时,溴代芳烃与仲胺的偶联反应在100℃下可顺利进行,最高分离收率达到95％.
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