合成了11种γ-氨基丁酸异硫氰酯偶联去甲斑蝥素与取代苯胺目标化合物,其结构经IR、 ~1H NMR和HR-MS测试技术确证.抗惊厥活性初步测定表明,化合物Ⅱ_2、Ⅱ_3和Ⅱ_8显示了较强的抗惊厥活性.
In order to find new anticonvulsant compounds,we designed and synthesized eleven target compounds of γ-aminobutyric acid isothiocyanate conjugated norcantharidin and substituted anilin. The structures were identified by IR,~1H NMR and HR-MS. Preliminary test of anticonvulsant activity shows that compounds Ⅱ_2,Ⅱ_3 and Ⅱ_8 have appreciable antiepileptic activity.
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