采用洗滤-萃取法去除原子转移自由基聚合法(ATRP)制备的聚甲基丙烯酸甲酯-聚L-乳酸-聚甲基丙烯酸甲酯(PMMA-b-PLLA-6-PMMA)嵌段共聚物中残留金属Cu离子.结果表明,采用二氯甲烷(DCM)溶解共聚物,用水或酸水洗滤-萃取,当重复洗滤-萃取5次后,cu离子的去除率能达到99%,所得嵌段共聚物的收率高于80%.与过A12O3层析柱或溶剂溶解-沉淀方法相比,洗滤-萃取法操作简单、可节省大量的有机溶剂,具有工业化前景.
参考文献
| [1] | LI Wentao,TANG Songchao.The Biodegradable Polymer Material[J].Shanghai Plastics,2002,(1):3-7 (in Chinese).李文涛,唐颂超.生物降解性高分子材料[J].上海塑料,2002,(1):3-7. |
| [2] | Teng C Q,Yang K,Ji P,et al.Synthesis and Characterization of Poly (L-Lactic acid) -Poly (ε-caprolactone) Muhiblock Copolymers by Melt Polyeondensation[J].Polym $ci,Part A:Polym Chem,2004,42:5045-5053. |
| [3] | Baras B,Benoit M A,Gillard J.Parameters Influencing the Antigen Release from Spray-dried Poly(DL-lactide)Micropartieles[J].Int J Pharm,2000,200:133-145. |
| [4] | Chung Tze-Wen,HuangY Y,Liu Y Z.Effects of the Rate of Solvent Evaporation on the Characteristics of Drug Loaded PLLA and PDLLA Mieruspheres[J].Int J Pharm,2001,212:161-169. |
| [5] | LIU Tianqi.Synthese and Characterization of Polymandelide and Lactide/methacrylate Block Copolymers[D].Lasning:Michigan State University,2002:23 |
| [6] | PENG Hui,LI Xiaoqin,CHENG Shiyuan,et al.Properties of Poly (n-Butyl Methacrylate) Prepared by Reverse Atom Transfer Radical Polymerization in Aqueous Dispersed System[J].Chinese J Colloid Polym,2004,22 (3):1-4 (in Chinese).彭慧,李小琴,程时远,等.反向ATRP乳液聚合法合成聚甲基丙烯酸丁酯的性能研究[J].胶体与聚合物,2004,22(3):1-4. |
| [7] | Zampano G,Bertoldo M,Bronco S.Poly (ethyl acrylate) Surface-initiatad ATRP Grafting from Wood Pulp Cellulose Fibers[J].Carbohydr Polym,2009,75:22-31. |
| [8] | Tong L,Shen Z,Zhang S,et al.Synthesis and characterization of Perfluorocyclobutyl Aryl Ether-based Amphiphilic Diblock Copolymer[J].Polymer,2008,49:4534-4540. |
| [9] | LI Juan,DUAN Ming,FANG Shenwen,et al.Synthesis of Cyclo-PMMA via Click Chemistry Combined with ATRP[J].Chem J Chinese Univ,2007,(6):1197-1199(in Chinese).李娟,段明,方申文,等.ATRP与点击化学相结合制备环状聚甲基丙烯酸甲酯[J].高等学校化学学报,2007,(6):1197-1199. |
| [10] | Wang H Y,Guo C Y,Dong J Y.Catalytic Synthesis and Characterization of Well-Defined Polypropylene Graft Copolymers[J].Catal Commun,2008,10:61-67. |
| [11] | Wang K,Liang L Y,Lin S L,et al.Synthesis of Well-Defined ABC Triblock Copolymers with Polypeptide Segments by ATRP and Click Reactions[J].Eur Polym J,2008,44:3370-3376. |
| [12] | Matyjaszewski K,Pintauer T,Gaynor S.Removal of Copper Based Catalyst in Atom Transfer Radical Polymerization using Ion Exchange Resins[J].Macromolecules,2000,33:1476-1478. |
| [13] | LIU Ying.Synthesis and Characterization of Poly(L-lactic acid) and Its copolymer[D].Nanjing:Nanjing University of Technology,2008:68 (in Chinese).刘迎.聚L-乳酸及其共聚物的合成与表征[D].南京:南京工业大学,2008. |
| [14] | Kokorin A I,Vlasova N N,Pridantsev A A,et al.Spectroscopic Study of Ternary Copper (Ⅱ) Complexes on a Silica Surface[J].Russ Chem Bull,1997,10:1670-1676.. |
| [15] | Kulkarni R K,Pani K C,Neuman C,et al.Polylactic Acid for Surgical Implants[J].Arch Surg,1966,93:839-843. |
| [16] | LIU Ying,WEI Rongqing,WEI Jun,et al.Purification of Lactide by Recrystallization with Alternating Solvents and Its Influence on Polymerization[J].J Chem Eng Chinese Univ,2008,22:1055-1070(in Chinese).刘迎,魏荣卿,魏军,等.丙交酯交替溶剂重结晶纯化法及其对聚合的影响[J].高校化学工程学报,2008,22:1055-1070. |
| [17] | XU Shaoling,XU Qiheng,TIAN Yingchao,et al.Inorganic Chemistry Series(Vol 6)[M].Beijing:Science Publishing Company,1998:474-480(in Chinese).徐绍龄,徐其亨,田应朝,等.无机化学系列丛书(第6卷)[M].北京:科学出版社,1998:474480. |
| [18] | Shen Y Q,Tang H D,Ding S J.Catalyst Separation in Atom Transfer Radical Polymerization[J].Prog Polym Sci,2004,29:1053-1078. |
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