针对Rhuschalcone Ⅰ的结构特征,将其切为2个合成片断:化合物8和化合物10,然后将2个片断连接.以间苯二酚和对羟基苯甲醛为起始原料,经选择性甲基化、碘代、甲氧甲基化、羟醛缩合、Ullmann反应和脱保护等步骤,完成了Rhuschalcone Ⅰ的合成.关键中间体与最终产物的化学结构经1H NMR、13C NMR和ESI-MS等表征及分析予以确认.
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