从中药粉防己中提取粉防己碱.在无水乙醇中粉防已碱分别与M(NO3)2·3H2O(M=Cu,Zn,Co,Ni)反应,合成了4种新的金属配合物,其结构分别用FT-IR和UV等测试技术进行了表征.应用微量量热仪分别测定了不同浓度的粉防己碱及4种粉防己碱的金属配合物、M( NO3)2 ·3H2O(M=Cu,Zn,Co,Ni)对大肠杆菌代谢作用的热功率-时间曲线,运用Logistic方程计算出细菌的生长速率常数,建立了生长速率常数与药物浓度间的关系,进而确定了最佳抑菌浓度.结果表明,4种金属配合物的抑菌作用均比M(NO3)2·3H2O和粉防己碱强.
参考文献
| [1] | ZHEN Pan.Research Progress of Tetrandrine[J].Chinese J Med Res,2004,33(8):30-32(in Chinese).甄攀.粉防己碱的研究进展[J].医学研究杂志,2004,33(8):30-32. |
| [2] | WANG Xuetao,LIU Jianping.Research Summary of Metal Complexes Drugs[J].Chinese J Cap Med,2000,7(10):20-21(in Chinese).王雪涛,刘建平.金属络合物药物研究概述[J].首都医药,2000,7(10):20-21. |
| [3] | WANG Caiping,LU Haifeng,ZHANG Honglin,et al.Drug Resistance of E.coli to Tetrandrine and Alkaloids of Stephenia tetrandra S.Moore by Microcalorimetry[J].Chinese J Appl Chem,2006,23(8):942-944(in Chinese).王彩萍,卢海峰,张洪林,等.微量量热法研究大肠杆菌对粉防己碱和粉防己总生物碱的耐药性[J].应用化学,2006,23(8):942-944. |
| [4] | ZHANG Jie.Extraction Process Improvement of Stephenia Tetrandra S.Moore[J].Chinese J Lishizhen Med Mater Med Res,2004,15(1):15-15(in Chinese).张杰.粉防己提取工艺的改进[J].时珍国医国药,2004,15(1):15-15. |
| [5] | SUN Wenji,ZHANG Dengke,DANG Zhiwen.Extraction Separation and Preparation of Natural Ingredient[M].Beijing:Chinese Medicine and Technology Publishing House,1994:374(in Chinese).孙文基,张登科,党治稳.天然药物成分提取分离与制备[M].北京:中国医药科技出版社,1994:374. |
| [6] | YANG Lahu,FU Xiaoyong,ZHU Jihong.Preparationes and Quality Analysises of Chemical Reference Substances of the Tetrandrine and Fangchinoline[J].Chinese J Pharm Anal,1989,9(4):216-218(in Chinese).杨腊虎,傅小勇,朱霁红.粉防己碱和防己诺林碱化学对照品的制备及质量分析[J].药物分析杂志,1989,9(4):216-218. |
| [7] | ZHANG Honglin,LIU Yongjun,NAN Zhaodong,et al.Establishment of the Microorganism Growth Model at an Inhibitory Condition by Microcalorimetric Method[J].Chinese J Biotechnol,1994,10(4):333-337 (in Chinese).张洪林,刘永军,南照东,等.应用微量热法构建限制性条件下微生物生长模型[J].生物工程学报,1994,10(4):333-337. |
| [8] | XIE Jingxi.Application of IR in Organic Chemistry and Medicine Chemistry[M].Chapt.18.Beijing:Seience Press,1987(in Chinese).谢晶曦.红外光谱在有机化学和药物化学中的应用[M].第18章.北京:科学出版社,1987. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%