以N-(5-氯-2-羟基苄基)氨基酸及其酯为配体,在室温下以水和甲醇为溶剂,采用分步法,以1∶1的摩尔比将配体与金属离子在弱碱性条件下混合,合成了20种未见报道的N-(5-氯-2-羟基苄基)氨基酸类金属配合物.用核磁、红外和紫外光谱技术对其结构进行了表征.证明在配合物中配体N-(5-氯-2-羟基苄基)氨基酸的羟基、胺基和羧基均参与了配位.抑菌测试表明,N-(5-氯-2-羟基苄基)氨基酸类金属配合物的抑菌活性普遍高于其配体,尤其对白色念珠菌的抑菌效果更为明显,均高达100%.对N-(5-氯-2-羟基苄基)席夫碱氨基酸酯的合成方法进行了优化,得到了较佳的合成工艺条件.
参考文献
| [1] | DU Jun,ZHANG Junhao,FANG Bin.Properties and Applications of Amino-acid Complex[J].Prog Chem,2003,15(4):288-294(in Chinese).杜俊,张俊豪,方宾.氨基酸配合物的性质与应用[J].化学进展,2003,15(4):288-294. |
| [2] | Praveen K S,Ram N H,Bhowon M G,et al.Synthesis and Characterization of Some Transition Metal Complexes of N-(2-Hydroxyl-Naphthylidene) Amino Acids[J].Inorg Met Org Chem,1996,26 (7):1219-1230. |
| [3] | Wang Mingzhao,Meng Zhaoxing,Liu Boli,et al.Novel Tumor Chemotherapeutic Agents and Tumor Radio-imaging Agents:Potential Tumor Pharmaceuticals of Ternary Copper(Ⅱ) Complexes[J].Inorg Chem Commun,2005,(8):368-371. |
| [4] | Douglas B G,Camil J.Oxidative Addition of the C-O Bond of Amino Acid Esters to Rh (Ⅰ) Forming Chelating Acyl Complexes[J].Inorg Chim Acta,2004,10 (357):3047-3056. |
| [5] | LI Jinzhou,AN Yumei,WANG Tianchi,et al.Synthesis,Characterization and Bioactivity of Rare Earth Complexes of Thenoylpyrazolone-amino-acid[J].Chinese J Inorg Chem,2004,20 (8):983-986 (in Chinese).李锦州,安郁美,王天赤,等.噻吩甲酰基吡唑啉酮缩氨基酸稀土配合物的合成、表征及生物活性[J].无机化学学报,2004,20(8):983-986. |
| [6] | ZHANG Jianmin,LI Ruifang,LIU Shuxiang.A Relation Between Stability of Transition Metal Schiff Base Complexes and Their Disinfectivity[J].Chinese J Inorg Chem,1999,15(4):493-496(in Chinese).张建民,李瑞芳,刘树祥.过渡金属配合物的稳定性及其杀菌活性[J].无机化学学报,1999,15(4):493-496. |
| [7] | BI Siwei,GAO Enqing,TIAN Junlian,et al.Synthesis,Characterization and Antibacterial Actity of N-Salicylideneamino Acid 3d Metal Complexes[J].Chinese J Appl Chem,1995,12(6):14-16(in Chinese).毕思玮,高恩庆,田君濂,等.N-亚水杨基3d金属配合物的合成、表征和抑菌活性[J].应用化学,1995,12(6):14-16. |
| [8] | Nyarku S K,Mavuso E.Preparation,Characterization and Biological Evaluation of a Chromium(Ⅱ) Schiff Bases Complexes Derived from o-Nitrobenzaldehyde and p-Amino-phenyl[J].South African J Chem,1998,51 (4):168-173. |
| [9] | Eichhorn G L,Marchand N D.The Stabilization of the Salicylaldehydeglycine Schif Base Though Metal Complex Formation[J].J Am Chem Soc,1956,12(78):2688-2691. |
| [10] | Aminabhavi T M,Biradar N S,Patil S B,et al.Amino Acids Schiff Base Complexes of Dimethyldichlorosilane[J].Inorg Chem Acta,1985,107(4):231-235. |
| [11] | Saidul Islam M,Farooque M A,Bodruddoza M A K,et al.Antimicrobial and Toxicological Studies of Mixed Ligand Transition Metal Complexes of Schiff Bases[J].J Biol Sci,2001,1(8):711-713. |
| [12] | LIU Qian,LU Junrui,XIN Chunwei,et al.Synthesis,Characterization and Antibacterial Activity of N-o-Hydroxybenzyl-amino Acid[J].J Tianjin Univ Technol,2006,26(2):12-14(in Chinese).刘倩,卢俊瑞,辛春伟,等.N-邻羟苯基氨基酸酯亚胺化合物的合成、表征及抑菌活性[J].天津理工大学学报,2006,26(2):12-14. |
| [13] | LIU Fang,LU Junrrui,XIN Chunwei,et al.Synthesis,Characterization and Antibacterial Properties of Halogenated o-Hydroxybenzyl-glutamates and There Esters[J].Chinese J Appl Chem,2009,26(10):1165-1168(in Chinese).刘芳,卢俊瑞,辛春伟,等.卤代邻羟苄基谷氨酸(酯)的合成、表征及抑菌活性[J].应用化学,2009,26(10):1165-1168. |
| [14] | LU Junrui,MA Xiamiao,LIU Mci.Hydrolysis and Intra-molecular Condensation of o-Aminodiphenyl Ether Diazonium Salts[J].Chem J Chinese Univ,2007,28(11):2081-2085(in Chinese).卢俊瑞,马霞苗,刘梅.邻氨基二苯醚类重氮盐的水解及分子内缩合反应[J].高等学校化学学报,2007,28(11):2081-2085. |
| [15] | LIU Fang,LU Junrui,CHEN Liran,et al.Synthesis Characterization and Antibacterial Activity of N-Chlorine-o-Hydroxybenzyl-amino Acid[J].J Tianjin Univ Technol,2009,25(3):28-32(in Chinese).刘芳,卢俊瑞,陈丽然,等.氯代邻羟基苄基氨基酸的合成、表征及活性研究[J].天津理工大学学报,2009,25(3):28-32 |
| [16] | Casella L,Gullotti M.Stereochemistry of Zinc(Ⅱ) and Copper(Ⅱ) Complexes of N-(2-pyridylmethylidene)amino Acids[J].Inorg Chem,1983,22(16):2259-2266. |
| [17] | WANG Bingqin,LI Zhichang.The Preparation and Application of Amino Ester[J].Amino Acids Biotic Resour,1995,17(4):40-45(in Chinese).王炳琴,黎植昌.氨基酸酯的制备方法及应用[J].氨基酸与生物资源,1995,17(4):40-45. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%