基于多靶向策略设计合成了氧化异阿朴菲-褪黑素杂合化合物,测试了它们的抗胆碱酯酶性能及相应的抑制动力学、抗氧化能力和抑制乙酰胆碱酯酶诱导的β-淀粉样蛋白(Aβ)聚集能力.实验结果表明,所合成的化合物对乙酰胆碱酯酶具有中等强度抑制力,其抑制IC50值在微摩尔浓度水平,属于非竞争性抑制剂；对乙酰胆碱酯酶诱导的Aβ淀粉样蛋白聚集的抑制率达到79.3％ ～ 84.7％；抗氧化能力是trolox的1.1～1.5倍.
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