以丙烯酰胺-β-环糊精和聚甲基丙烯酸缩水甘油酯为功能单体,乙二醇二甲基丙烯酸酯为交联剂,采用原位聚合法制备了聚丙烯酸酯-β-环糊精手性毛细管整体柱.通过红外和扫描电子显微镜表征了整体柱固定相的结构和形貌.并以苯丙氨酸为考察物考察了柱子的稳定性和重现性,柱效达到47701 plates/m,获得了良好的分离效果.在毛细管电色谱模式下,采用丙烯酰胺-β-环糊精整体柱首次拆分盐酸依替福林对映体,结果使盐酸依替福林对映体达到了基线分离.
参考文献
| [1] | Shabi A Z,Seung M L,Zeid A A L O,et al.Examination of Template Structural Effects on CEC Chiral Separation Performance of Molecule Imprinted Polymers Made by a Generalized Preparation Protocol[J].Chromatographia,2011,73:517-525. |
| [2] | WU Yi,ZHANG Xiaohui,WEI Juan,et al.Recent Advances and Applications of Capillary Electrochromatography and Pressurized Capillary Electrochromatography[J].Chinese J Chromatogr,2009,27 (5):609-620(in Chinese).吴漪,张晓晖,魏娟,等.毛细管电色谱和加压毛细管电色谱的进展与应用[J].色谱,2009,27(5):609-620. |
| [3] | WANG Qianru.Capillary Electrochromatography Research Progress and Application in Pharmaceutical Analysis[J].Heilongjiang Med Pharm,2010,33(5):26-27(in Chinese).王倩如.毛细管电色谱的研究进展及其在药物分析中的应用[J].黑龙江医药科学,2010,33(5):26-27. |
| [4] | ZHENG Wei,LIN Hongmei,LI Na,et al.Capillary Electrochromatography and Its Applications in the Analysis of Chinese Traditional Medicine[J].China Med Herald,2009,6(36):95-96 (in Chinese).郑威,林红梅,李娜,等.毛细管电色谱及其在中药分析中的应用[J].中国医药报导,2009,6(36):95-96. |
| [5] | Peter S,Leif S,Lars 1 A,et al.Novel Vinylpyridine Based Cationic MIP Monoliths for Enantiomer Separation in CEC[J].Chromatographia,2009,69:277-285. |
| [6] | GAO Wenhui,YANG Guijun,ZHAO Wenwei,et al. Preparation Technology and Application of Capillary Monolithic Column[J].Chem Res Appl,2009,21 (9):1223-1230 (in Chinese).高文惠,杨桂君,赵文伟,等.毛细管整体柱的制备技术及其应用进展[J].化学研究与应用,2009,21(9):1223-1230. |
| [7] | CHEN Li,ZHU Kang,YAO Chuanyi. Progress on Chiral Organic Polymer-based Monoliths for Capillary Electrochromatography[J].J Instrum Anal,2010,29 (12):1235-1240 (in Chinese).陈利,朱康,姚传义.手性有机聚合物毛细管电色谱整体柱研究进展[J].分析测试学报,2010,29(12):1235-1240. |
| [8] | YANG Shengkai,ZHANG Yuping,FAN Liqun,et al. Enantiomeric Separation of Gepefrine by Capillary Electro-chromatography[J].J Instrum Anal,2009,28(5):608-610(in Chinese).杨胜凯,张裕平,范立群,等.吉培福林对映体的毛细管电色谱分离[J].分析测试学报,2009,28(5):608-610. |
| [9] | Tian Y,Zhong C,Fu E Q,et al.Novelβ-Cyclo dextrin Derivative Functionalizedpolymethacrylate-Based Monolithic Columns for Enantio Selective Separation of Ibuprofen and Naproxenen Antiomers in Capillary Electrochromatography[J]. J Chromatogr A,2009,1216 (6):1000-1007. |
| [10] | LEI Wen,ZHANG Lingyi,WAN Li,et al.Preparation and Evaluation of an Eremomycin-Bonded Chiral Monolithic Column for Capillary Electrochromatography[J].Chinese J Chromatogr,2010,28(10):977-983 (in Chinese).雷雯,张陵怡,万莉,等.伊瑞霉素键合手性毛细管整体柱的制备与对映体分离[J].色谱,2010,28(10):977-983. |
| [11] | YAN Junlin,LIU Jing,CHEN Xi,et al.Studies on the Host-Gust Interaction Between Quaternary Ammonium Salt of N,N'-Bis (ferrocenylmethylene) diaminobutane andβ-Cyclodextrin Modified Poly (acrylamide)[J].Acta China Sin,2007,65:1779-1783 (in Chinese).严军林,刘静,陈希,等.N,N’-双二茂铁亚甲基丁二胺季铵盐和侧链携带β-环糊精的聚丙烯酰胺的合成及相互间的主客体包结作用[J].化学学报,2007,65:1779-1783. |
| [12] | Jun-S K,Young Ky P,Keun H C,et al.Preparation of N-Acryloyl and N-(N-Acryloylglycinyl) Derivatives of 2-Acetoamido-2-deoxy-β-D-glucopyranosylamine[J].Bull Korean Chem Soc,2001,22 (7):758-760. |
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