用含氨基的偶联剂修饰介孔分子筛MCM-41的表面,将修饰前和修饰后的介孔分子筛分别负载难溶性药物萘普生(NAP),利用X射线衍射、傅里叶变换红外光谱、差示扫描量热分析、扫描电子显微镜、透射电子显微镜和N2吸附-脱附分析等技术分别对其进行了结构表征和性能测试.结果表明,药物分子存在于分子筛的孔道中.负载在MCM-41中的萘普生溶出速率远优于原料药,60 min时大约溶出70％.氨基修饰后的药物释放速率比修饰前有所减慢,表明可通过氨基修饰调节释放速率.
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