合成了3,5-二碘水杨醛缩邻苯二胺席夫碱合镍(Ⅱ)配合物.通过核磁共振、元素分析、紫外光谱、红外光谱及摩尔电导对结构进行了表征,用Gaussian03程序优化计算,确定配合物的结构为Ni(Ⅱ)L.通过紫外光谱、粘度法及与溴化乙锭(EB)的竞争实验,研究了配合物与小牛胸腺DNA(ct-DNA)的作用情况.结果显示,配合物与DNA作用时,紫外吸收发生明显的减色效应,其结合常数为Kb=1.129×105 L/mol;EB-DNA体系的荧光强度随配合物的加入迅速减弱；配合物的加入使ct-DNA的粘度增加.这些结果表明,该化合物以插入式与ct-DNA键合.并用打孔法测试了配合物对藤黄微球菌(M.luteus)的抑制作用.
参考文献
| [1] | David C,Daniel G.Synthesis of a 4,6-Disubstituted Dibenzofuran Sheet Initiator by Reductive Radical Arylation of Benzene[J].J Org Chem,2005,70(6):2384-2386. |
| [2] | Gao A P,Wang M,Wang D,et al.A Symmetric Oxidation of Sulfides Catalyzed by Vanadium(Ⅳ) Complexes of Dibromo 2-and Diiodo-functionalized Chiral Schiff Bases[J].Chinese J Catal,2006,27(8):743-748. |
| [3] | Desai S B,Desai P B,Desai K R.Synthesis of Some Schiff Bases Thiazo-lidinones and Azetidinones from 2,6-Diaminobonzol[1,2-d:4,5-d]' Bisthiazole and Their Anti-cancer Activities[J].Hetercycl Commun,2001,(7):83-90. |
| [4] | Hodnett E M,Dunn W J.An Titumor Activities of Some Schiff Bases[J].Med Chem,1970,13:768-770. |
| [5] | GAO Min,YANG Tianlin,MA Zhiqiang,et al.Synthesis and Antibacterial Activity of Its Metal Complexes of Salicyhydrazide and 3,5-Diiodosalicylalidehyde Schiff Base[J].Chinese J Appl Chem,2011,28 (10):1167-1172 (in Chinese).高敏,杨天林,马志强,等.3,5-二碘水杨醛缩水杨酰肼Schiff碱及其金属配合物的合成与抑菌活性[J].应用化学,2011,28(10):1167-1172. |
| [6] | Marvin L Illingsworth,Wang W,Kenneth A Hughes,et al.Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry[J].Org Chem,2004,34(3):593-609. |
| [7] | LIANG Xuejun,XU Suoping.New Synthetic Method of Iodic Substituent Salicyladhyde[J].J Suzhou Univ,2008,23 (5):115-116(in Chinese).梁学军,徐锁平.碘代水杨醛合成的新方法[J].宿州学院学报,2008,23(5):115-116. |
| [8] | Xu S P,Zhu G Z,Fang R Q,et al.Syntheses and Crystal Structures of 3,5-Diiodo-salicylali-dehyde and 3,5-Diiodo-salicy-lalidene-4-nitroaniline[J].Chinese J Struct Chem,2009,28(1):87-93. |
| [9] | Geary W J.The Use of Conductivity Mearsurements in Organic Solvents for the Characterization Compounds[J].Coord Chem Rev,1971,7:81-122. |
| [10] | ZHANG Wenzhao,ZHOU Yantong,YU Baoyuan.Syntheses and Properties of 2,5-Bis-(2-hydroxyanilino) Methylenyl Thiophene Complexes of Cobalt(Ⅱ),Nickel(Ⅱ),Copper(Ⅱ),Silver(Ⅰ) and Lead(Ⅱ)[J].Chinese J Inorg Chem,1993,9 (2):216-220 (in Chinese).张文昭,周彦同,余宝源.Co(Ⅱ)、Ni(Ⅱ)、Cu(Ⅱ)、Ag(Ⅰ)和Pb(Ⅱ)的2,5-噻吩二甲醛双缩邻氨基苯酚希夫碱配合物的合成及性质的研究[J].无机化学学报,1993,9(2):216-220. |
| [11] | DU Jiasheng,LI Zihong,HUANG Yuanze,et al.Studies on Metal Complexes of Schiff Bases Containing Surfur Ⅱ[J].Chinese J Inorg Chem,1994,10(1):47-52(in Chinese).杜家声,李自弘,黄渊泽,等.含硫希夫碱配合物的研究Ⅱ[J].无机化学学报,1994,10(1):47-52. |
| [12] | Frisch M J,Trucks G W,Schlegel H B,et al.Gaussian,Inc.Gaussian 03,Revision B.04,Pittsburgh PA,2003. |
| [13] | ZHANG Zhaohong,ZANG Shuliang,SU Xin,et al.Investigation on Interaction of Tributyltin Compound with DNA by Spectroscopy[J].Chinese J Spectrosc Lab,2005,22 (4):819-823 (in Chinese).张朝红,臧树良,苏欣,等.三丁基锡化合物与DNA相互作用的光谱研究[J].光谱实验室,2005,22(4):819-823. |
| [14] | Purcell M,Neault J F,Riahi T.Interaction of Taxol with Human Serum Albumin[J].Biochem Biophys Acta,2000,1478(1):61-68. |
| [15] | Liu J,Zhang T X,Lu T B,et al.DNA-binding and Cleavage Studies of M acrocyclic Copper(Ⅱ) Complexes[J].J Inorg Biochem,2002,91 (1):269-. |
| [16] | Lakowicz J R,Weber G.Quenching of Fluorescence by Oxygen.A Probe for Structural Fluctuations in Macromolecules[J].Biochemistry,1973,12(21):4161-4170. |
| [17] | SHU Cui.Optimizing the Fermentation Conditions,Mutant Breeding,Gene Cloning,Expression and Purification of Catalase a from Micrococcus Luteus[D].Shanghai:Donghua University,2010 (in Chinese).疏翠.藤黄微球菌过氧化氢酶发酵条件优化、诱变育种及其基因的克隆、表达纯化[D].上海:东华大学,2010. |
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