WalPhos配体/铑配合物对β,γ-不饱和膦酸酯的不对称催化氢化

应用化学, 2014, 31(2): 242-244. doi: 10.3724/SP.J.1095.2014.30194

WalPhos配体/铑配合物对β,γ-不饱和膦酸酯的不对称催化氢化

段正超 ^1, , 王联芝 ^2, , 左晓宇 ^3, , 屈桃李 ^4, , 胡向平 ^5, , 郑卓 ^6,

1.湖北民族学院化学与环境工程学院恩施445000

2.湖北民族学院化学与环境工程学院恩施445000

3.湖北民族学院化学与环境工程学院恩施445000

4.湖北民族学院化学与环境工程学院恩施445000

5.中国科学院大连化学物理研究所大连116023

6.中国科学院大连化学物理研究所大连116023

基金项目: 教育部重点项目(211111) 国家自然科学基金项目(21262011) the National Natural Science Foundation of China(21262011) the Key Project of Chinese Ministry of Education(211111)

关键词： β-取代β , γ-不饱和膦酸酯 , 不对称催化氢化 , 铑 , 手性β-芳基取代丙基膦酸酯

Rh-catalyzed Asymmetric Hydrogenation of β, γ-Unsaturated Phosphonates with WalPhos Ligands

Keywords： β-substituted β , γ-unsaturated phosphonates , asymmetric catalytic hydrogenation , rhodium , chiral β-aryl-substituted propylphosphonates

用手性配体(Rc,Sp)-WalPhos与铑形成的配合物为催化剂,在1.0 MPa的氢气压力、二氯甲烷溶剂中以及室温的反应条件下,对β-取代β,γ-不饱和膦酸酯底物进行不对称催化氢化,合成了具有β-手性中心的手性膦酸酯类化合物,所有考察的底物均可完全转化,最高获得了87％的ee值.

参考文献

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材料期刊网

WalPhos配体/铑配合物对β,γ-不饱和膦酸酯的不对称催化氢化

Rh-catalyzed Asymmetric Hydrogenation of β, γ-Unsaturated Phosphonates with WalPhos Ligands

参考文献