首次合成了二茂铁基-1,3,4-三唑Schiff碱衍生物(5a ～5e),利用IR、1 H NMR和HRMS等手段对其进行了结构表征.用黄瓜子叶生根法以及小麦芽鞘法,分别测试化合物的细胞分裂素活性和生长素活性.结果表明,在10 mg/L浓度下,有4个化合物的子叶生根促进作用为46.9％～73.6％,比对参照物的细胞分裂活性更高,但生长素活性不明显,化合物5c仅提高25％;化合物的除草活性在68％～72％之间.以石墨烯修饰的玻碳电极为工作电极,在Britton-Robison缓冲溶液中,研究了目标化合物电化学行为.结果表明,在pH值为2或3的溶液中,合成目标化合物具有良好的氧化还原可逆性,氧化峰电流对数(lg Ipc)与扫描速度对数(lgv)、浓度对数(lg c)均呈现良好线性关系,目标化合物(5a～5d)的电子转移过程均受吸附-扩散混合控制,该类化合物的循环伏安法最低检出限为10-5 moL/L.
参考文献
| [1] | WANG Rui.The Electrochemical Characterization of Ferrocene Derivatives and Their Application in Biosensor[D].Wuhan:Nanchang University,2008(in Chinese).王瑞.二茂铁衍生物的电化学性质及在生物传感中的应用[D].武汉:南昌大学,2008. |
| [2] | LIN Changjiang.Research on the Synthesis and Biological Activity of Novel Triazole Containing Ferrocenyl[D].Tianjin:Nankai University,2003(in Chinese).林长江.含二茂铁基的新型三唑类化合物的合成及生物活性研究[D].天津:南开大学,2003. |
| [3] | CAI Yanlin.Studies on the Structure and Bioactivity of Ferrocene-containing ComplexesD].Guangxi:Guangxi Normal University,2007(in Chinese).蔡艳林.含二茂铁配合物的结构及生物活性的研究[D].广西:广西师范大学,2007. |
| [4] | FU Quejun.Research on the Synthesis and Antibacterial Activities of Several Novel Ferrocene Schiff BaseD].Shanxi:Shaanxi University of Technology,2009(in Chinese).傅雀军.新型含二茂铁基杂环胺Schiff碱的合成与抑菌性能研究[D].陕西:陕西科技大学,2009. |
| [5] | Bai G,Graham M D,Abbott N L.Role of Desorption Kinetics Determining Marangoni Flows Generated by Using Electrochemical Methods and Redox-active Surfactants[J].Langmuir,2005,21:2235-2241. |
| [6] | Gallardo B S,Hwa M J,Abbott N L.In Situ and Reversible Control of the Surface Activity of Ferrocenyl Surfactants in Aqueous Solutions[J].Langmuir,1995,11:4209-4212. |
| [7] | Aydogan N,Gallardo B S,Abbott N.A Molecular-thermodynamic Model for Gibbs Monolayers Formed from Redox-active Surfactants at the Surfaces of Aqueous Solutions:Redox-induced Changes in Surface Tension[J].Langmuir,1999,15:722-730. |
| [8] | Gallardo B S,Abbott N L.Active Control of Interfacial Properties:A Comparison of Dimeric and Monomeric Ferrocenyl Surfactants at the Surface of Aqueous Solutions[J].Langmuir,1997,13:203-208. |
| [9] | Anna P,Jolanta R,Liliana M,et al.Synthesis,Structure Elucidation and Antitumorur Activity of N-Substituted Amides of 3-(3-Ethylthio-1,2,4-triazol-5-y]) Propenoic Acid[J].Eur J Med Chem,2009,(44):3788-3793. |
| [10] | Subrahmanya K,Bo ja P,Jagadeesh.Synthesis and Antitumor Activity Studies of Some New Fused 1,2,4-Triazole Derivatives Carrying 2,4-Dichloro-5-fluo-rophenyl Moiety[J].Eur J Med Chem,2009,(44):2066-2074. |
| [11] | Haber J.Present Status and Perspectives on Antimycotics with Systematic Effects[J].Cas LEK Cesk,2001,140:596-604. |
| [12] | ZHENG Yuguo,WEI Xue,GUO QingQing,et al.Sythesis and Biologica Activities of Novel Bistriazolyl-3(2H)-pyridazinones[J].Chinese J Appl Chem,2011,28(9):1028-1034(in Chinese).郑玉国,魏学,郭晴晴,等.双三唑希弗碱哒嗪酮衍生物的合成及其生物活性[J].应用化学,2011,28(9):1028-1034. |
| [13] | Sun X H,Tao Y,Liu Y F,et al.Synthesis and Biological Activities of Substituted Triazolethione Schiff Base[J].ChineseJ Chem,2007,25:1573-1576. |
| [14] | SHI Haijiang,WANG Zhongyi,SHI Haoxin.Synthesis and Antibacterial Activities of 3,6-Disubstituted-5,6-dihydrogen-1,2,4-S-triazolo-[3,4-b]-1,3,4-thiadiazoles[J].Pharm Sin,2011,36(4):310-312(in Chinese).史海健,王忠义,史好新.3,6-二取代-5,6-二氢-l,2,4-均三唑并[3,4-b]-l,3,4-噻二唑的合成及抗菌活性[J].药学学报,2011,36(4):310-312. |
| [15] | LIU Chenjiang,XIE Zhengfeng,LI Yanping,et al.Synthesis of l,2,4-Triazole[3,4-b]-1,3,4-thiadiazoles[J].Chem Res Appl,2005,17(5):657-660(in Chinese).刘晨江,解正峰,李燕萍,等.1,2,4-三唑并[3,4-b]-1,3,4-噻二唑的合成[J].化学研究与应用,2005,17(5):657-660. |
| [16] | Erhan P,Gulay S,Pelin K,et al.Synthesis and Anti-inflammatory Activity of 1-Acylthiosemicarbazides,1,3,4-Oxadiazoles,1,3,4-Thiadiazoles and 1,2,4-Triazole-3-thiones[J].IlFarmaco,2002,(57):101-107. |
| [17] | Zhan P,Chen X,Li X,et al.Stuying Synergism of Methyl Linked Cyclohexyl Thiopnes with Triazole:Synthesis and Their Cdk5/p25 Inhibition Activity[J].Eur J Med Chem,2011,(46):2066-2074. |
| [18] | Bucche l L H,Draber W.Ger Offen 1940628,1971.Chem Abstr,1971,74,No.125698t. |
| [19] | Bianchi D,Cesti P,Spezia S,et al.Chemoenzymic Synthesis and Biological Activity of Both Enantiomeric Forms of Tetraconazole,A New Antifungal Tria-zole[J].JAgric Food Chem,1991,(39):197-201. |
| [20] | Simmons K A,Dixson J A,Halling B P,et al.Synthesis and Activity Optimization of Herbicidal Substituted 4-Aryl-1,2,4-triazole-5 (1 H)-thiones[J].J Agric Food Chem,1992,40:297-305. |
| [21] | Wang B L,Shi Y X,Ma Y,et al.Synthesis and Biological Activity of Some Novel Trifluoromethyl-Substituted 1,2,4-Triazole and Bis (1,2,4-Triazole) Mannich Bases Containing Piperazine Rings[J].J Agric Food Chem,2010,58:5515-5522. |
| [22] | Kennethkl L,Rinehart J,Kaye L,et al.Organic Chemistry of Ferrocene the Acetylation of Dialkylferrocenes[J].J Am Chem Soc,1957,79 (11):2749-2754. |
| [23] | DAI Chaofeng,HUI Xinping,ZHANG Linmei,Synthesis of Thiosemicarbazide Triazole containing Ferrocenyl and Furodiazole[J].J Lanzhou Univ,2002,38 (5):51-57 (in Chinese).戴朝峰,惠新平,张林梅,等.含二茂铁基的氨基硫脲均三唑和噁二唑的合成[J].兰州大学学报,2002,38(5):51-57. |
| [24] | Ho Y S,McKay G.Pseudo-second Order Model for Sorption Processes[J].Process Biochem,1999,34(5):451-465. |
| [25] | J Christopher Love,Daniel B Wolfe,Richard Haasch.Formation and Structure of Self-assembled Monolayers of Alkanethiolates on Palladium[J].JAm Chem Soc,2003,125:2597-2609. |
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