过去十几年里,量子点从材料科学到生命科学、从基础研究到实际应用都开展了广泛的研究.量子点在生物成像、光治疗、药物/基因转运、太阳能电池等领域均具有广泛的应用.通过调节量子点的表面性质,实现量子点与细胞相互作用的可控性是一个关键的问题.伴随着量子点潜在毒性问题的产生,纳米毒性成为纳米材料安全性评估的重要指标,并且受到科学家们的高度关注.本文综述了量子点的特性、细胞生物学应用及在生物医药领域相关的细胞毒性研究,并展望了量子点的未来发展趋势.
参考文献
[1] | Li F,Chen H,Ma L,et al.Insights into Stabilization of a Viral Protein Cage in Templating Complex Nanoarchitectures:Roles of Disulfide Bonds[J].Small,2014,10(3):536-543. |
[2] | Haldar K K,Sen T,Patra A.Metal Conjugated Semiconductor Hybrid Nanoparticle-Based Fluorescence Resonance Energy Transfer[J].J Phys Chem C,2010,114:4869-4874. |
[3] | Weaver J E,Dasari M R,Datar A,et al.Investigating Photoinduced Charge Transfer in Carbon Nanotube-Perylene-Quantum Dot Hybrid Nanocomposites[J].ACS Nano,2010,4:6883-6893. |
[4] | Louie A.Multimodality Imaging Probes:Design and Challenges[J].Chem Rev,2010,110:3146-3195. |
[5] | Zhu H,Song N,Lian T.Charging of Quantum Dots by Sulfide Redox Electrolytes Reduces Electron Injection Efficiency in Quantum Dot Sensitized Solar Cells[J].J Am Chem Soc,2013,135:11461-11464. |
[6] | Justo Y,Goris B,Kamal J S,et al.Multiple Dot-in-Rod PbS/CdS Heterostructures with High Photoluminescence Quantum Yield in the Near-Infrared[J].J Am Chem Soc,2012,134:5484-5487. |
[7] | Bigall N C,Parak W J.Polymer Coating of Quantum Dots for Excellent Colloidal Stability[J].Protocal Excahnge,2012,doi:10.1038/protex.2012.043. |
[8] | ZHANG Chuanzhou,TAN Hui,MAO Yan,et al.Synthesis and Properties of Luminescent Carbon Dots and Its Applications[J].Chinese J Appl Chem,2013,30(4):367-372(in Chinese).张川洲,谭辉,毛燕,等.发光碳量子点的合成、性质和应用[J].应用化学,2013,30(4):367-372. |
[9] | WU Yuqin,CHEN Jinlong.Sensitive Detection of L-Cysteine by Using Blue Luminescent Gold Quantum Dots[J].Chinese JAppl Chem,2013,30(2):225-231(in Chinese).吴玉芹,陈金龙.水溶性发光金量子点灵敏检测L-半胱氨酸[J].应用化学,2013,30(2):225-231. |
[10] | YIN Pengfei,GONG Huiping,LIU Zhengqing,et al.Determination of Jatrorrhizine Hydrochloride by Core-shell CdTe/CdS Quantum Dots with Fluorescence Quenching Method[J].ChineseJAppl Chem,2012,29(3):320-326(in Chinese).殷鹏飞,龚会平,刘正清,等.紫外-可见吸收、荧光光谱研究CdTe/CdS量子点与盐酸药根碱的相互作用及其应用[J].应用化学,2012,29 (3):320-326. |
[11] | U Pingping,YIN Pengfei,GONG Huiping,et al.A Study on the Interaction Between CdTe/CdS Quantum Dots with Mitomycin C and Its Analytical Application[J].Chinese J Appl Chem,2012,29(3):320-326.(in Chinese).李萍萍,殷鹏飞,龚会平,等.CdTe/CdS量子点与丝裂霉素的相互作用及其应用[J].应用化学,2012,29(6):705-710. |
[12] | Liu H,Tang J,Kramer LJ,et al.Electron Acceptor Materials Engineering in Colloidal Quantum Dot Solar Cells[J].Adv Mater,2012,23:3832-3837. |
[13] | Scheibner M,Schmidt T,Worschech L,et al.Superradiance of Quantum Dots[J].Nat Phys,2007,3:106-110. |
[14] | Luo Q Y,Lin Y,Li Y,et al.Nanomechanical Analysis of Yeast Cells in CdSe Quantum Dot Biosynthesis[J].Small,2014,10(4):699-704. |
[15] | Katsnelson M I,Novoselov K S,Geim A K.Chiral Tunnelling and the Klein Paradox in Graphene[J].Nat Phys,2006,2:620-625. |
[16] | Sanderson K.A Small Industry could be on the Verge of a Boom,Reports Katharine Sanderson[J].Nature,2009,459:760-761. |
[17] | Dickerson M B,Sandhage K H,Naik R R.Protein-and Peptide-Directed Syntheses of Inorganic Materials[J].Chem Rev,2008,108:4935-4978. |
[18] | Singh S C,Mishra S K,Srivastava R K,et al.Optical Properties of Selenium Quantum Dots Produced with Laser Irradiation of Water Suspended Se Nanoparticles[J].J Phys Chem C,2010,114:17374-17384. |
[19] | Tikhomirov G,Hoogland S,Lee PE,et al.DNA-based Programming of Quantum Dot Valency,Self-assembly and Luminescence[J].Nat Nano 2011,6:485-490. |
[20] | Kim T H,Cho K S,Lee E K,et al.Full-colour Quantum Dot DisplaysFabricated by Transfer Printing[J].Nat Photon,S:176-182. |
[21] | Kamat PV,Quantum Dot Solar Cells.Semiconductor Nanocrystals as Light Harvesters[J].J Phys Chem C,2008,112:18737-18753. |
[22] | Li F,Chen Y,Chen H,et al.Monofunctionalization of Protein Nanocages[J].J Am Chem Soc,2011,133:20040-20043. |
[23] | Chan W C,Nie S.Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection[J].Science,1998,281:2016-2018. |
[24] | Bruchez M,Moronne M,Gin P,et al.Semiconductor N anocrystals as Fluorescent Biological Labels[J].Science,1998,281:2013-2016. |
[25] | Liu J,Lau SK,Varma VA,et al.Multiplexed Detection and Characterization of Rare Tumor Cells in Hodgkin's Lymphoma with Multicolor Quantum Dots[J].Anal Chem,2010,82:6237-6243. |
[26] | Liu J,Lau S K,Varma V A,et al.Molecular Mapping of Tumor Heterogeneity on Clinical Tissue Specimens with Multiplexed Quantum Dots[J].ACS Nano,2010,4:2755-2765. |
[27] | Liu SL,Li J,Zhang ZL,et al.Fast and High-Accuracy Localization for Three-Dimensional Single-Particle Tracking[J].Sci Rep,2013,doi:10.1038/srep02462. |
[28] | Cassette E,Pons T,Bouet C,et al.Synthesisand Characterization of Near-Infrared CuInSe/ZnS Core/Shell Quantum Dots for in vivo Imaging[J].Chem Mater,2011,22:6117-6124. |
[29] | Midgett AG,Hillhouse HW,Hughes BK,et al.Flowing versus Static Conditions for Measuring Multiple Exciton Generation in PbSe Quantum Dots[J].J Phys Chem C,2010,114:17486-17500. |
[30] | Lord S J,Lee H l D,Moerner W E.Single-Molecule Spectroscopy and Imaging of Biomolecules in Living Cells[J].Anal Chem,2010,82:2192-2203. |
[31] | Vannoy C H,Xu J,Leblanc R M.Bioimaging and Self-Assembly of Lysozyme Fibrils Utilizing CdSe/ZnS Quantum Dots[J].J Phys Chem C,2009,114:766-773. |
[32] | Neo M S,Venkatram N,Li G S,et al.Synthesis of PbS/CdS Core-Shell QDs and Their Nonlinear Optical Properties[J].J Phys Chem C,2010,114:18037-18044. |
[33] | Rehberg M,Praetner M,Leite CF,et al.Quantum Dots Modulate Leukocyte Adhesion and Transmigration Depending on Their Surface Modification[J].Nano Lett,2010,10:3656-3664. |
[34] | Medintz I L,Uyeda H T,Goldman E R,et al.Quantum Qot Bioconjugates for Iimaging,Labelling and Sensing[J].Nat Mater,2005,4:435-446. |
[35] | Allen P M,Bawendi M G.Ternary Ⅰ-Ⅲ-Ⅵ Quantum Dots Luminescent in the Red to Near-Infrared[J].JAm Chem Soc,2008,130:9240-9241. |
[36] | Mandal A,Tamai N.Influence of Acid on Luminescence Properties of Thioglycolic Acid-Capped CdTe Quantum Dots[J].J Phys Chem C,2008,112:8244-8250. |
[37] | Lee S,Xie J,Chen X.Peptides and Peptide Hormones for Molecular Imaging and Disease Diagnosis[J].Chem Rev,2010,110:3087-311 1. |
[38] | Murray C B,Norris D J,Bawendi M G.Synthesis and Characterization of Nearly Monodisperse CdE(E =sulfur,selenium,tellurium) Semiconductor Nanocrystallites[J].J Am Chem Soc,1993,115:8706-8715. |
[39] | Hines M A,Guyot-Sionnest P.Synthesis and Characterization of Strongly Luminescing ZnS-Capped CdSe Nanocrystals[J].J Phys Chem,1996,100:468-471. |
[40] | Peng Z A,Peng X.Formation of High-Quality CdTe,CdSe,and CdS Nanocrystals Using CdO as Precursor[J].J Am Chem Soc,2000,123:183-184. |
[41] | Vossmeyer T,Katsikas L,Giersig M,et al.CdS Nanoclusters:Synthesis,Characterization,Size Dependent Oscillator Strength,Temperature Shift of the Excitonic Transition Energy,and Reversible Absorbance Shift[J].J Phys Chem,1994,98:7665-7673. |
[42] | Akerman M E,Chant W C W,Laakkonen P,et al.Nanoorystal Targeting in vivo[J].Proc Nat Acad Sci USA,2002,99:12617-12621. |
[43] | Mamedova N N,Kotov N A,Rogach A L,et al.Albumin-CdTe Nanoparticle Biooonjugates:Preparation,Structure,and Interunit Energy Transfer with Antenna Effect[J].Nano Lett,2001,1:281-286. |
[44] | Putzer M A,Rogers J S,Bazan G C.Intramolecular Nucleophilic Substitution on Coordinated Borabenzenes:A New Entry into Boratabenzene Complexes[J].J Am Chem Soc,1999,121:8112-8113. |
[45] | Dabbousi B O,Rodriguez-Viejo J,Mikulec F V,et al.(CdSe) ZnS Core-Shell Quantum Dots:Synthesis and Characterization of a Size Series of Highly Luminescent Nanocrystallites[J].J Phys Chem B,1997,101:9463-9475. |
[46] | Kim S,Fisher B,Eisler H-Jr,et al.Type-Ⅱ Quantum Dots:CdTe/CdSe (Core/Shell) and CdSe/ZnTe (Core/Shell) Heterostructures[J].J Am Chem Soc,2003,125:11466-11467. |
[47] | Gao X,Yang L,Petros JA,et al.In vivo Molecular and Cellular Imaging with Quantum Dots[J].Curr Opin Chem Biol,2005,16:63-72. |
[48] | Wilson R,Spiller D G,Prior I A,et al.A Simple Method for Preparing Spectrally Encoded Magnetic Beads for MultiplexedDetection[J].ACS Nano,2007,1:487-493. |
[49] | Kumar R,Ding H,Hu R,et al.In vitro and In vivo Optical Imaging Using Water-Dispersible,Noncytotoxic,Luminescent,Silica-Coated Quantum Rods[J].Chem Mater,2010,22:2261-2267. |
[50] | Green M,Howman E.Semiconductor Quantum Dots and Free Radical Induced DNA Nicking[J].Chem Commun,2005,1:121-123. |
[51] | Cho SJ,Maysinger D,Jain M,et al.Long-Term Exposure to CdTe Quantum Dots Causes Functional Impairments in Live Cells[J].Langmuir,2007,23:1974-1980. |
[52] | Mahto S K,Park C,Yoon T H,et al.Assessment of Cytocompatibility of Surface-modified CdSe/ZnSe Quantum Dots for BALB/3T3 Fibroblast Cells[J].Toxico In Vitro,2010,24:1070-1077. |
[53] | Shan Y,Wang Z,Hao X,et al.Locating the Band Ⅲ Protein in Quasi-native Cell Membranes[J].Anal Meth 2010,2:805-808. |
[54] | Jiang J,Hao X,Cai M,et al.Localization of Na+-K+ ATPases in Quasi-native Cell Membranes[J].Nano Lett,2009,9:4489-4493. |
[55] | Neuhauser R G,Shimizu K T,Woo W K,et al.Correlation Between Fluorescence Intermittency and Spectral Diffusion in Single Semiconductor Quantum Dots[J].Phys Rev Lett,2000,85:3301-3304. |
[56] | Dubertret B,Skourides P,Norris D J,et al.In Vivo Imaging of Quantum Dots Encapsulated in Phospholipid Micelles[J].Science,2002,298:1759-1762. |
[57] | Rieger S,Kulkami R P,Darcy D,et al.Quantum Dots are Powerful Multipurpose Vital Llabeling Agents in Zebrafish Embryos[J].Developmental Dynamics,2005,234:670-681. |
[58] | Jaiswal J K,Mattoussi H,Mauro J M,et al.Long-term Multiple Color Imaging of Live Cells Using Quantum Dot Bioconjugates[J].Nat Biotech,2003,21:47-51. |
[59] | Hanaki K-i,Momo A,Oku T,et al.Semiconductor Quantum Dot/Albumin Complex is a Long-life and Highly Photostable Endosome Marker[J].Biochem Biophys Res Commun,2003,302:496-501. |
[60] | Mansson A,Sundberg M,Balaz M,et al.In Vitro Sliding of Actin Filaments Labelled with Single Quantum Dots[J].Biochem Biophys Res Commun,2004,314:529-534. |
[61] | Kaul Z,Yaguchi T,Kaul S C,et al.Mortalin Imaging in Normal and Cancer Cells with Quantum Dot Immuno-conjugates[J].Cell Res,2003,13:503-507. |
[62] | Sukhanova A,Devy Jrm,Venteo L,et al.Biocompatible Fluorescent Nanocrystals for Immunolabeling of Membrane Proteins and Cells[J].AnalBiochem,2004,324:60-67. |
[63] | Nisman R,Dellaire G,Ren Y,et al.Application of Quantum Dots as Probesfor Correlative Fluorescence,Conventional,and Energy-filtered Transmission Electron Microscopy[J].J Histochem Cytochem,2004,52:13-18. |
[64] | Rosenthal S J,Tomlinson I,Adkins E M,et al.Targeting Cell Surface Receptors with Ligand-oonjugated Nanoorystals[J].J Am Chem Soc,2002,124:4586-4594. |
[65] | Dahan M,Lavi S,Luccardini C,et al.Diffusion Dynamics of Glycine Receptors Revealed by Single-Quantum Dot Tracking[J].Science,2003,302:442-445. |
[66] | Lidke DS,Nagy P,Heintzmann R,et al.Quantum Dot Ligands Provide New Insights into ErbB/HER Receptor-mediated Signal Transduction[J].Nat Biotech,2004,22:198-203. |
[67] | Howarth M,Takao K,Hayashi Y,et al.Targeting Quantum Dots to Surface Proteins in Living Cells with Biotin Ligase[J].Proc Nat Acad Sci USA,2005,102:7583-7588. |
[68] | Giepmans B N G,Deerinck T J,Smarr B L,et al.Correlated Llight and Electron Microscopic Imaging of Multiple Endogenous Proteins Using Quantum Dots[J].Nat Meth,2005,2:743-749. |
[69] | Sundara Rajan S,Vu T Q.Quantum Dots Monitor TrkA Receptor Dynamics in the Interior of Neural PC12 Cells[J].Nano Lett,2006,6:2049-2059. |
[70] | Hoshino A,Fujioka K,Oku T,et al.Quantum Dots Targeted to the Assigned Organelle in Living Cells[J].Microbiol Immunol,2004,48:985-994. |
[71] | Santra S Y H,Stanley J T,Holloway P H,et al.Rapid and Effective Labeling of Brain Tissue using TAT-conjugated CdS:Mn/ZnS Quantum Dots[J].Chem Commun,2005,25:3144-3146. |
[72] | Pellegrino T,Parak WJ,Boudreau R,et al.Quantum Dot-based Cell Motility Assay[J].Differentiation,2003,71:542-548. |
[73] | Mattheakis L C,Dias J M,Choi Y J,et al.Optical Coding of Mammalian Cells using Semiconductor Quantum Dots[J].Anal Biochem,2004,327:200-208. |
[74] | Ramachandran S,Merrill N E,Blick R H,et al.Colloidal Quantum Dots Initiating Current Bursts in Lipid Bilayers[J].Biosens Bioelectron,2005,20:2173-2176. |
[75] | Kloepfer J A,Mielke R E,Wong M S,et al.Quantum Dots as Strain-and Metabolism-Specific Microbiological Labels[J].Appl Environ Microbiol,2003,69:4205-4213. |
[76] | Marshall D,Pedley R B,Boden J A,et al.Polyethylene Glycol Modification of a Galactusylated Streptavidin Clearing Agent:Effects on Immunogenicity and Clearance of a Biotinylated Anti-tumour Antibody[J].Br J Cancer,1996,73:565-572. |
[77] | Cai W,Shin D W,Chen K,et al.Peptide-Labeled Near-Infrared Quantum Dots for Imaging Tumor Vasculature in Living Subjects[J].Nano Lett,2006,6:669-676. |
[78] | Lim YT,Kim S,Nakayama A,et al.Selection of Quantum Dot Wavelengths for Biomedical Assays and Iimaging[J].Mol lmaging,2003,2:50-64. |
[79] | Frangioni J V.In Vivo Near-infrared Fluorescence Imaging[J].Curr Opin Chem Biol,2003,7:626-634. |
[80] | So M K,Xu C,Loening A M,et al.Self-illuminating Quantum Dot Conjugates for in Vivo Imaging[J].Nat Biotech,2006,24:339-343. |
[81] | Brannon-Peppas L,Blanchette J O.Nanoparticle and Targeted Systems for Cancer Ttherapy[J].Adv Drug Deliver Rev,2004,.56:1649-1659. |
[82] | Peracchia M T,Fattal E,Desmele D,et al.Stealth@PEGylated Polycyanoacrylate Nanoparticles for Intravenous Administration and Splenic Targeting[J].J Control Release,1999,60:121-128. |
[83] | Porkka K,Laakkonen P,Hoffman JA,et al.A Fragment of the HMGN2 Protein Homes to the Nuclei of Tumor Cells and Tumor Endothelial Cells In Vivo[J].Proc Nat Acad Sci USA,2002,99:7444-7449. |
[84] | Morgan NY,English S,Chen W,et al.Real Time In Vvivo Non-invasive Optical Iimaging using Near-infrared Fluorescent Quantum Dots[J].Acad Radiol,2005,12:313-323. |
[85] | Chen L,Zurita AJ,Ardelt PU,et al.Design and Validation of a Bifunctional Ligand Display System for Receptor Targeting[J].Chem Biol,2004,11:1081-1091. |
[86] | Ballou B,Lagerholm BC,Ernst LA,et al.Noninvasive Imaging of Quantum Dots in Mice[J].Biocon Chem,2003,15:79-86. |
[87] | Gao X,Cui Y,Levenson RM,et al.In Vivo Cancer Targeting and Iimaging with Semiconductor Quantum Dots[J].Nat Biotech,2004,22:969-976. |
[88] | Chang S S,Reuter V E,Heston WDW,et al.Metastatic Renal Cell Carcinoma Neovasculature Expresses Prostate-specific Membrane Antigen[J].Urology,2001,57:801-805. |
[89] | Hoffman R M.Green Fluorescent Protein Imaging of Tumour Growth,Metastasis,and Angiogenesis in Mouse Models[J].Lancet Oncol,2002,3:546-556. |
[90] | Yang M,Baranov E,Wang JW,et al.Direct External Imaging of Nascent Cancer,Tumor Progression,Angiogenesis,and Metastasis on Internal Organs in the Fluorescent Orthotopic Model[J].Proc Nat Acad Sci USA,2002,99:3824-3829. |
[91] | Akerman M E,Chan W C W,Laakkonen P,et al.Nanocrystal Targeting in Vivo[J].Proc Nat Acad Sci USA,2002,99:12617-12621. |
[92] | Jamieson T,Bakhshi R,Petrova D,et al.Biological Applications of Quantum Dots[J].Biomaterials,2007,28:4717-4732. |
[93] | Larson D R,Zipfel W R,Williams RM,et al.Water-Soluble Quantum Dots for Multiphoton Fluorescence Imaging in Vivo[J].Science,2003,300:1434-1436. |
[94] | Jakub JW,Pendas S,Reintgen DS.Current Status of Sentinel Lymph Node Mapping and Biopsy:Facts and Controversies[J].The Oncologist,2003,8:59-68. |
[95] | Parungo C P,Colson Y L,Kim S W,et al.Sentinel Lymph Node Mapping of the Pleural Space[J].Chest J,2005,127:1799-1804. |
[96] | Cimmino V M,Brown A C,Szocik J F,et al.Allergic Reactions to Isosulfan Blue during Sentinel Node Biopsy Common Event[J].Surgery,2001,130:439-442. |
[97] | Soltesz E G,Kim S,Laurence R G,et al.Intranperative Sentinel Lymph Node Mapping of the Lung Using Near-Infrared Fluorescent Quantum Dots[J].Ann Thorac Surg,2005,79:269-277. |
[98] | Kim S H,Suh H J,Koh K N,et Surface Plasmon Resonance Study on the Interaction of Photochromic Spironaphthoxazine with L-phenylalanine in Self-assembled Monolayers on Gold[J].Dyes Pigm,2004,62:93-97. |
[99] | Parungo C P,Ohnishi S,Kim S W,et al.Intraoperative Identification of Esophageal Sentinel Lymph Nodes with Near-infrared Fluorescence Imaging[J].J Thorac Cardiov Sur,2005,129:844-850. |
[100] | Tanaka E,Choi H,Fujii H,et al.Image-Guided Oncologic Surgery Using Invisible Light:Completed Pre-Clinical Development for Sentinel Lymph Node Mapping[J].Ann Surg Oncol,2006,13:1671-1681. |
[101] | Lee LY,Ong SL,Hu JY,etal.Use of Semiconductor Quantum Dots for Photostable Immunofluorescence Labeling of Cryptosporidium Parvum[J].Appl Environ Microbiol,2004,70:5732-5736. |
[102] | Zhu L,Ang S,Liu W T.Quantum Dots as a Novel Immunofluorescent Detection System for Cryptosporidium parvum and Giardialamblia[J].Appl Environ Microbiol,2004,70:597-598. |
[103] | Yang L,Li Y.Simultaneous Detection of Escherichia Coli O157[ratio]H7 and Salmonella Typhimurium Using Quantum Dots as Fluorescence Llabels[J].Analyst,2006,131:394-401. |
[104] | Tully E,Hearty S,Leonard P,et al.The Development of Rapid Fluorescence-based Immunoassays,Using Quantum Dotlabelled Antibodies for the Detection of Listeria Monocytogenes Cellsurface Proteins[J].Int J Biol Macromol,2006,39:127-134. |
[105] | Modun B,Morrissey J,Williams P.The Staphylococcal Transferrin Receptor:a Glycolytic Enzyme with Novel Functions[J].Trend Microbiol,2000,8:231-237. |
[106] | Gerion D,Chen F,Kannan B,et al.Room-Temperature Single-Nucleotide Polymorphism and Multiallele DNA Detection Using Fluorescent Nanocrystals and Microarrays[J].Anal Chem,2003,75:4766-4772. |
[107] | Agrawal A,Tripp R A,Anderson L J,et al.Real-Time Detection of Virus Particles and Viral Protein Expression with Two-Color Nanoparticle Probes[J].J Virology,2005,79:8625-8628. |
[108] | Goldman E R,Anderson G P,Tran P T,et al.Conjugation of Luminescent Quantum Dots with Antibodies Using an Engineered Adaptor Protein To Provide New Reagents for Fluoroimmunoassays[J].Anal Chem,2002,74:841-847. |
[109] | Goldman E R,Balighian E D,Mattoussi H,et al.Avidin:A Natural Bridge for Quantum Dot-Antibody Conjugates[J].J Am Chem Soc,2002,124:6378-6382. |
[110] | Goldman E R,Clapp A R,Anderson G P,et al.Multiplexed Toxin Analysis Using Four Colors of Quantum Dot Fluororeagents[J].Anal Chem,2003,76:684-688. |
[111] | Park H Y,Kim K,Hong S,et al.Compact and Versatile Nickel-Nitrilotriacetate-Modified Quantum Dots for Protein Imaging and Fol^rster Resonance Energy Transfer Based Assay[J].Langmuir,2009,26:7327-7333. |
[112] | Derfus A M,Chan W C W,Bhatia S N.Probing the Cytotoxicity of Semiconductor Quantum Dots[J].Nano Lett,2003,4:11-18. |
[113] | Tan S J,Jana N R,Gao S,et al.Surface-Ligand-Dependent Cellular Interaction,Subcellular Localization,and Cytotoxicity of Polymer-Coated Quantum Dots[J].Chem Mater,2010,22:2239-2247. |
[114] | Qu Y,Li W,Zhou Y,et al.Full Assessment of Fate and Physiological Behavior of Quantum Dots Utilizing Caenorhabditis elegans as a Model Organism[J].Nano Lett,2011,11:3174-3183. |
[115] | Navarro D A G,Watson D F,Aga D S,et al.Natural Organic Matter-Mediated Phase Transfer of Quantum Dots in the Aquatic Environment[J].Environ Sci Technol,2009,43:677-682. |
[116] | Maity A R,Jana N R,Chitosan-Cholesterol-Based Cellular Delivery of Anionic Nanoparticles[J].J Phys Chem C,2010,115:137-144. |
[117] | Kirchner C,Liedl T,Kudera S,et al.Cytotoxicity of Colloidal CdSe and CdSe/ZnS Nanoparticles[J].Nano Lett,2004,5:331-338. |
[118] | Su Y,Hu M,Fan C,et al.The Cytotoxicity of CdTe Quantum Dots and the Relative Contributions from Released Cadmium Iions and Nanoparticle Properties[J].Biomaterials,2010,31:4829-4834. |
[119] | Chang E,Yu W W,Colvin V L,et al.Quantifying the Influence of Surface Coatings on Quantum Dot Uptake in Cells[J].J Biomed Nanotech,2005,1:397-401. |
[120] | Clark R J,Dang M K M,Veinot J G C.Exploration of Organic Acid Chain Length on Water-Soluble Silicon Quantum Dot Surfaces[J].Langmuir,2010,26:15657-15664. |
[121] | Li Y,Zhou Y,Wang H Y,et al.Chirality of Glutathione Surface Coating Affects the Cytotoxicity of Quantum Dots[J].Angew Chem Int Ed Engl,2011,50:5860-5864. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分:
-
10%
-
20%
-
30%
-
40%
-
50%