以L-脯氨酸支载在功能化离子液体四氟硼酸1-(2-羟乙基)3.甲基咪唑鎓盐上的离子液体([Promim] CF3CO2)为催化剂兼溶剂,可在温和条件下顺利地催化硝基乙烷、硝基甲烷和各种醛的Henry缩合反应,目标产物的产率达79％～ 95％,非对映选择性可达3∶1,对映选择性可达85％ ee.反应操作和后处理简单方便.[Promim] CF3CO2离子液体通过简单的处理即可实现循环利用,以邻-硝基苯甲醛和硝基乙烷为反应底物的模板反应,这种离子液体可以较稳定地循环使用6次,催化活性不降.
参考文献
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