采用超声法制备齐墩果酸(OA)与烷醇胺(EAs)[单乙醇胺(MEA)、二乙醇胺(DEA)或三乙醇胺(TEA)]复合物,利用差示扫描量热、X射线衍射、红外光谱和拉曼光谱等技术手段对复合物进行了表征.发现OA与EA之间无新的化学键形成,它们以分子间力结合形成复合物.OA与EA复合物提高了OA的溶解度,为OA新型给药系统提供新思路和理论依据.
参考文献
| [1] | WANG Long,MA Li,HAN Feng,et al.Optimization of Prescriptions of Dispersible Tablets of Oleanolic Acid[J].Tianjin JTradit Chinese Med,2011,28(2):161-163(in Chinese).王龙,马莉,韩锋,等.齐墩果酸分散片的处方优化[J].天津中医药,2011,28(2):161-163. |
| [2] | TIAN Yan,JIANG Ni,TIAN Ge,et al.Preparation and Quality Check of Oleanolic Acid Microcapsules[J]..JDalian Med Univ,2007,29 (2):1118-1119(in Chinese).田燕,蒋妮,田舸,等.齐墩果酸微囊的制备及质量考察[J].大连医科大学学报,2007,29(2):118-1119. |
| [3] | XIANG Daxiong,TAO Yufei,WANG Feng,et al.Studies on Formation and Solubilizing Mechanism of Oleanolic Acid Solid Dispersion[J].Chinese Tradit Herb Drugs,2002,33(4):311-314(in Chinese).向大雄,陶昱斐,王峰,等.齐墩果酸固体分散体形成和增溶机制研究[J].中草药,2002,33(4):311-314. |
| [4] | Liu L X,Wang X C.Solubility of Oleanolic Acid in Various Solvents from (288.3 to 328.3)K[J].JChem Eng Data,2007,52:2527-2528. |
| [5] | LI Hualong,YIN Dongdong,WANG Xinlin.Solubilizing Techniques Their Application to Water-insoluble Drug Preparation[J].Tianjin Pharm,2010,22(1):60-67(in Chinese).李华龙,尹东东,王杏林.难溶性药物的制剂增溶技术及应用[J].天津药学,2010,22(1):60-67. |
| [6] | FENG Caixia,XU Hui,WANG Shaoning,et al.Improvement of Transdermal Permeation of Flurbiprofen via Complex Salts Formation with Triethanolamine[J].JShenyang Pharm Univ,2008,25 (4):255-257(in Chinese).冯彩霞,徐晖,王绍宁,等.三乙醇胺复合物促进氟比洛芬体外经皮透过[J].沈阳药科大学学报,2008,25(4):255-257. |
| [7] | LU Guoqing,ZHENG Jiang,ZHENG Xinchuan,et al.Preparation and Characterization of Oridonin Phospholipid Complex[J].Acta Acad Med Mil Tert,2010,32(20):2220-2223(in Chinese).陆国庆,郑江,郑新川,等.冬凌草甲素磷脂复合物的制备及其性质研究[J].第三军医大学学报,2010,32(20):2220-2223. |
| [8] | Fang L,Numajiri S,Kobayashi D,et al.Physicochemical and Crystallographic Characterization of Mefenamic Acid Complexes with Alkanomines[J].J Pharm Sci,2004,93(1):144-154. |
| [9] | Han H K,Choi H K.Improved Absorption of Meloxicam via Salt Formation with Ethanolamines[J].Eur J Pharm Biopharm,2007,65(1):99-103. |
| [10] | Gwak H S,Choi J S,Choi H K.Enhanced Bioavailability of Piroxicam via Salt Formation with Ethanolamines[J].Int J Pharm,2005,297:156-161. |
| [11] | Chinese Pharmacopoeia Commission.Pharmacopoeia of People' s Republic of China (part2),Appendix XIXJ:208[M].Beijing:The Medicine Science and Technology Press of China,2010(in Chinese).国家药典委员会.中华人民共和国药典(二部),附录XIXJ:20S[M].北京:中国医药科技出版社,2010. |
| [12] | SUN Yuqing,HU Yuzhu.Analytical Chemistry[M].Beijing:Science Press,2009:331-333(in Chinese).孙毓庆,胡育筑.分析化学[M].第2版.北京:科学出版社,2009:331-333. |
| [13] | CHEN Yizhang,ZHANG Jinlin,JIA Mingyin,et al.Absorption of Poly(methyl methacrylate) on Nano-alumina and Bound carbonyls[J].Chem.JChinese Univ,2010,31(10):2093-2097(in Chinese).陈艺章,张锦琳,贾明印,等.聚甲基丙烯酸甲酯在纳米氧化铝表面的吸附和氢键作用[J].高等学校化学学报,2010,31(10):2093-2097. |
| [14] | LI Jianzhang.Discussion on the Influence of Intermolecular Hydrogen Bonding on the Properties of Organic Compounds[J].Zigong Teachers College J,2003,18(2):89-92(in Chinese).李建章.浅谈分子间氢键对有机化合物性质的影响[J].自贡师范高等专科学校学报,2003,18(2):89-92. |
| [15] | LIU Anchang,ZHAO Lixia,ZHAI Guangxi,et al.An Investigation on Formation Mechanisms and Preparation of Curcumin Phospholipid Complex[J].China.JChinese Mater Med,2008,17(33):2112-2117(in Chinese).刘安昌,赵丽霞,翟光喜,等.姜黄素磷脂复合物的制备及其形成机制研究[J].中国中药杂志,2008,17(33):2112-2117. |
| [16] | WU Lianzhong,KE Chuizhong,SONG Genping.Analysis of Oleanolic Acid with Raman Spectroscopy[J].Chinese Tradit Herb Drugs,1995,26(5):227-228,238(in Chinese).吴练中,柯椎中,宋根萍.齐墩果酸的拉曼光谱分析[J].中草药,1995,26(5):227-228,238. |
| [17] | WU Lianzhong,KE Chuizhong.Testing Structure Characters of the Efective Ingredients of the Traditional Chinese Medicine with Raman Soectroscopy[J].Spectrosc Spear Anal,1995,15 (6):51-54(in Chinese).吴练中,柯椎中.激光拉曼光谱法验证中草药有效成分的结构特征[J].光谱学与光谱分析,1995,15(6):51-54. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%