二氯乙酸钠电纺纤维毡改善宫颈癌小鼠生存质量

应用化学, 2014, 31(7): 763-769. doi: 10.3724/SP.J.1095.2014.30537

二氯乙酸钠电纺纤维毡改善宫颈癌小鼠生存质量

1.中国科学院长春应用化学研究所长春 130022;中国科学院大学北京 100049

2.中国科学院长春应用化学研究所长春 130022

3.中国科学院长春应用化学研究所长春 130022

4.中国科学院长春应用化学研究所长春 130022

基金项目: 国家自然科学基金(51273194,51021003,50733003,21174143) the National Natural Science Foundation of China(51273194,51021003,50733003,21174143) 吉林省科技厅项目(20100588) Jilin Provincial Science and Technology Department(20100588)

关键词：宫颈癌 , 二氯乙酸钠 , 静电纺丝 , 生存质量

Improved Suvival Quality of Mice with Cervical Cancer Through the Therapy of Sodium Dichloroacetateloaded Electrospun Mats

Keywords： cervical cancer , sodium dichloroacetate , electropsun mats , suvivial quality

通过溶液静电纺丝的方法,将水溶性药物二氯乙酸钠(DCA)包裹入油溶性聚乳酸(PLA)中,制备出二氯乙酸钠电纺纤维毡.将其应用于宫颈癌的活体实验中,结果表明在为期19 d的治疗下,荷瘤小鼠的肿瘤抑制率达到94％,总体康复率达到38％.同时,DCA电纺纤维毡还极大地抑制了宫颈癌后期复发和转移的趋势,提高了荷瘤小鼠的生存质量,是一种安全且疗效确切的抗癌给药剂型.

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