将壳聚糖改性为(2-羟基-3-丁氧基)丙基-羟丙基壳聚糖(2-H-3-B-P-HPCS),并以(2-羟基-3-丁氧基)丙基-羟丙基壳聚糖和聚乙二醇(PEG)为原料制备(2-羟基-3-丁氧基)丙基-羟丙基壳聚糖/聚乙二醇互穿网络凝胶,研究了(2-羟基-3-丁氧基)丙基-羟丙基壳聚糖浓度、聚乙二醇的用量、交联剂戊二醛用量、反应温度对该凝胶溶胀性能的影响.通过红外光谱分析和扫描电子显微镜的方法比较了壳聚糖、(2-羟基-3-丁氧基)丙基-羟丙基壳聚糖和(2-羟基-3-丁氧基)丙基-羟丙基壳聚糖/聚乙二醇互穿网络凝胶结构和形态上的不同.以阿昔洛韦为模型药物研究了其释药性能.结果表明,该凝胶均具有良好的溶胀性、pH敏感性和药物缓释作用,有望用作新型的药物载体.
参考文献
| [1] | 杨旭东;吴国杰;林玩金.壳聚糖水凝胶的制备及性能研究[J].化工新型材料,200533(12):48-50. |
| [2] | Risbud M V;Hardikar A A;Bhat S V.pH Sensitive Freeze-Dried Chitosan Polyvinyl Pyrrolidone Hydrogels as Controlled Release System for Antibiotic Delivery[J].Journal of Controlled Release,200068:23-30. |
| [3] | Martin L;Wilsona C G;Fariba K.Sustained Buccal Delivery of the Hydrophobic Drug Denbufylline Using Physically Cross-Linked Palmitoyl Glycol Chitosan Hydrogels[J].European Journal of Pharmaceutics and Biopharmaceutics,200355:35-45. |
| [4] | Lin Y H;Liang H F;Chung C K.A Non-covalently Cross-linked Chitosan Based Hydrogel[J].BIOMATERIALS,200526:2105-2113. |
| [5] | Montembault A;Viton C;Domard A.Rheometric Study of the Gelation of Chitosan in a Hydroalcoholic Medium[J].BIOMATERIALS,200526:1633-1643. |
| [6] | Majeti N V;Ravi K.A Review of Chitin and Chitosan Applications[J].Reactive & Functional Polymers,200046(01):1-27. |
| [7] | Campos J B;Lourencao B C;Omuro Lupetti K.Development of a Method Employing Chitosan to Remove Metallic Ions from Wastewater[J].Quimica Nova,200730(04):879-884. |
| [8] | 施亦东;季莉;陈衍夏.水溶性羟丙基壳聚糖的性能研究[J].四川大学学报(工程科学版),200638(03):100-104. |
| [9] | Noble L;Gray A I;Sadiq L.A Non-covalently Cross-linked Chitosan Based Hydrogel[J].International Journal of Pharmaceutics,1999192:173-182. |
| [10] | Martin L;Wilson C G;Koosha F.The Release of Model Macromolecules may be Controlled by the Hydrophobicity of Palmitoyl Glycol Chitosan Hydrogels[J].Journal of Controlled Release,200280(03):87-100. |
| [11] | Uchegbu I F;Schatzlein A G;Tetley L.Polymeric chitosan-based Vesicles for Drug Delivery[J].Journal of Pharmacy and Pharmacology,199850:453-458. |
| [12] | Ruel E G;Leclair G;Hildgen P.Thermosensitive Chitosan-based Hydrogel Containing Liposomes for the Delivery of Hydrophilic Molecules[J].Journal of Controlled Release,200282:373-383. |
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