口腔癌的发病率占全身恶性肿瘤的第6位,正确区分正常状态与良性和恶性口腔肿瘤,是恰当选择治疗方案的关键所在.本研究中,首先利用液相色谱-质谱和气相色谱-质谱联用方法分别得到健康人、良性口腔肿瘤患者和恶性口腔肿瘤患者血浆、尿液和唾液的代谢轮廓,然后应用正交信号校正的偏最小二乘法进行多变量统计分析.结果表明健康人、良性肿瘤患者和恶性肿瘤患者在血浆、尿液和唾液等3种体液代谢中都可以被区分开,而且找到和鉴定出19个重要差异代谢物.相关代谢通路分析显示,与健康人相比,良性和恶性口腔肿瘤患者都存在能量代谢紊乱和脂类代谢失衡的现象,但恶性口腔肿瘤患者还表现出三羧酸循环和肌醇代谢异常,这为临床诊断及治疗提供了重要信息.
参考文献
| [1] | Brandwein-Gensler M,Teixeira M S,Lewis C M,et al.Am J Surg Pathol,2005,29 (2):167 |
| [2] | Chen J,Wang W Z,Lv S,et al.Anal Chim Acta,2009,650(1):3 |
| [3] | Gao P,Lu C,Zhang F X,et al.Analyst,2008,133(9):1214 |
| [4] | Dai W D,Zhang F X,Jia Z H,et al.Chinese Journal of Chromatography(戴伟东,张凤霞,贾振华,等.色谱),2011,29(11):1049 |
| [5] | Zhou J L,Xu B,Huang J,et al.Clin Chim Acta,2009,401(1/2):8 |
| [6] | Tiziani S,Lopes V,Günther U L.Neoplasia,2009,11 (3):269 |
| [7] | Yan S K,Wei B J,Lin Z Y,et al.Oral Oncol,2008,44(5):477 |
| [8] | Sugimoto M,Wong D T,Hirayama A,et al.Metabolomics,2010,6(1):78 |
| [9] | Navazesh M.Ann NY Acad Sci,1993,694(1):72 |
| [10] | Smilde A K,van der Werf M J,Bijlsma S,et al.Anal Chem,2005,77(20):6729 |
| [11] | Bruce S J,Tavazzi I,Parisod V,et al.Anal Chem,2009,81(9):3285 |
| [12] | Gika H G,Theodoridis G A,Wingate J E,et al.J Proteome Res,2007,6(8):3291 |
| [13] | Eriksson L,Johansson E,Kettaneh-Wold N,et al.Multiand Megavariate Data Analysis Principals and Applications.Umea,Sweden:Umetrics,2001 |
| [14] | Garber K.J Natl Cancer Inst,2004,96 (24):1805 |
| [15] | Taylor L A,Arends J,Hodina A K,et al.Lipids Health Dis,2007,6(1):17 |
| [16] | Kaur J,Sawhney M,DattaGupta S,et al.BMC Cancer,2010,10(1):168 |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%