建立了同时检测氯丙嗪、异丙嗪及其主要代谢物的毛细管电泳电致化学发光新方法.最佳实验条件为:检测电位1.20V,钌联吡啶浓度5 mmol/L,检测池磷酸缓冲溶液40 mmol/L( pH 6.5),分离磷酸缓冲溶液18 mmol/L(pH 4.8),进样电压11 kV,进样时间8s,分离电压13.5 kV.方法的检出限(3σ)分别为氯丙嗪8.3×10-7g/L、异丙嗪7.2×10-6g/L、氯丙嗪亚砜1.9×10-5 g/L和异丙嗪亚砜3.7×10-6 g/L,各组分的电化学发光强度和迁移时间的相对标准偏差( RSD)分别不超过3％和1％.本方法具有简便、快速、灵敏、进样量少和不受共存物干扰等特点,可在不必预分离的情况下直接同时连续测定家犬尿样中的氯丙嗪、异丙嗪、氯丙嗪亚砜和异丙嗪亚砜.
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