采用固相萃取对水样进行预处理,建立了同时检测地表水中包括抗生素、β-阻滞剂、驱蚊剂、抗癫痫药、中枢神经兴奋剂、血脂调节剂、非甾体抗炎药、杀菌消毒剂在内的18种药物与个人护理品的超高效液相色谱-串联质谱分析方法.采用中性条件萃取水样,控制上样流速为2 mL/min,用甲醇-乙腈(1∶1,v/v)溶液洗脱.纯水中的平均加标回收率为53.9％～112％,相对标准偏差为2.6％ ～ 15.3％(n=6)；以地表水样加标100 ng/L为样品,目标分析物平均回收率为45.1％～ 156.6％,相对标准偏差为2.4％～15.7％(n=6).结果表明,本方法可同时精确检测地表水样中的18种分析物,方法验证结果表明所建立的方法可靠.用该方法分析杭州余杭塘河水,结果检出9种分析物,其中咖啡因平均质量浓度达550.7 ng/L.结果表明该方法可靠.
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