在KH2PO4-Na2HPO4(pH 6.24±0.1)支持电解质中,N-(4-硝基-2-苯氧基苯基)(尼美舒利,nimesulide)甲基磺酰胺产生1个催化氢波,峰电位Ep=-1.20 V(vs.SCE).加入K2S2O8后,该催化氢波被催化,峰电流增加约20倍,峰电位基本不变,产生1个较灵敏的平行催化氢波.其二阶导数峰峰电流i"p与尼美舒利浓度在4.0×10-7～8.0×10-6 mol/L范围内呈线性关系(r=0.988 6,n=9),检出限为2.0×10-7 mol/L.该方法可用于药物制剂中尼美舒利含量的测定.
参考文献
| [1] | GUO Sheng-Cai(郭胜才),PAN Feng-Jun(潘峰君).West Chinese J Pharm(华西药学杂志)[J],2000,15(6):469 |
| [2] | WU Yan-Hui(武延辉),LI Wen-Jun(李文军),SHAO Guang-Zhou(邵广州).Chinese Hospi Pharm J(中国医院药学杂志)[J],1999,19(5):300 |
| [3] | Rainsford K D.Drugs Today[J],2001,37:3 |
| [4] | XIE Su-Jing(谢苏婧),XIE Bao-Mei(谢宝妹),JIA Rong-Zheng(贾荣征).Chinese J Instru Anal(分析测试学报)[J],2001,20(5):71 |
| [5] | ZENG Zhu(曾珠),ZHANG Han-Ping(张汉萍).Chinese Pharm J(中国药学杂志)[J],1996,31(10):610 |
| [6] | Syed A A,Amshumali M K,Devan N.Acta Chromatogr[J],2002,12:95 |
| [7] | Patravale V B,D'Souza S,Narkar Y.J Pharmaceut Biomed[J],2001,25(3～4):685 |
| [8] | Nagaralli B S,Seetharamappa J,Gowda B G,et al.J Anal Chem[J],2003,58(8):778 |
| [9] | Chen Y L,Wu Sh M.Anal Bioanal Chem[J],2005,381(4):90 |
| [10] | Catarino R I L,Conceiǎo A C L,Garcia M B Q,et al.J Pharm Biomed Anal[J],2003,33(4):571 |
| [11] | HUANG Hua-Long(黄华龙),LIN Jun(林军).Chinese J Modern Appl Pharm(中国现代应用药学杂志)[J],1998,15(8):55 |
| [12] | Murthy T K,Reddy M N,Reddy M D,et al.Asian J Chem[J],2001,13(3):915 |
| [13] | ZHANG Han-Ping(张汉萍),WU Xin-Yue(吴心悦),WANG Jian-Lin(王建林).J Tongji Medical Univ(同济医科大学学报)[J],1998,27(1):83 |
| [14] | GU Hai-Ning(顾海宁),LI Jian-Ping(李建平),LIANG Bang-Bin(梁帮斌).Part B Chem Anal(理化检验--化学分册)[J],2004,40(9):503 |
| [15] | Mairanovskii S G.J Electroanal Chem[J],1963,6:77 |
| [16] | Guo W,Liu LM,Lin H,et al.Sci China[J],2002,45(2):158 |
| [17] | Xu M T,Song J F,Li N,et al.J Electroanal Chem[J],2003,314:212 |
| [18] | Xu M T,Song J F,Liang Y D.J Pharm Biomed Anal[J],2004,34:681 |
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