由乙酸酐和H2O2在无硫酸存在下合成过氧乙酸,然后向其滴加1,5-二萘酚的甲醇溶液,在一锅内简便地合成了胡桃醌.产物用苯重结晶,其结构经HPLC、UV-Vis、FTIR、1H NMR和13C NMR测试技术进行了表征和证实.考察了原料摩尔比、反应温度和反应时间对产率的影响.最佳反应条件为:n(1,5-二萘酚)∶n(乙酸酐)∶n(H2O2)=1∶4∶8,反应温度为40～60 ℃,反应时间为5.5 h,产率68%.结果表明,一锅法合成不用硫酸,无需真空蒸馏纯化过氧乙酸,是合成胡桃醌的简便方法.
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