由壳聚糖(CS)、聚乙烯醇(PVA)和三聚磷酸钠(TPP)制备了壳聚糖/聚乙烯醇/三聚磷酸钠三元复合微球,探讨了体系中壳聚糖含量对复合微球的影响,以及离子种类及浓度和pH值对复合微球溶胀度的影响. 采用XRD、FTIR和SEM等测试技术对微球的组分、结构和形貌进行了表征. 结果表明,CS和PVA具有良好的相容性,随着CS含量的增加,PVA的结晶性逐渐降低,复合微球的粒径约为400～950 μm,表面较为粗糙;随着CS添加量的增加,凝胶平衡溶胀度先增大再减小,CS/PVA/TPP复合微球在pH值为3～8的溶胀度最大,且在同一种溶液中,随着离子浓度的增加,其溶胀度明显降低;复合微球具有溶胀-收缩可逆性,显示CS/PVA/TPP复合微球是pH/离子敏感型凝胶,可为药物缓释系统提供实验和理论依据.
Chitosan/polyvinyl alcohol/sodium tripolyphosphate complex microparticles were prepared from chitosan(CS), polyvinyl alcohol(PVA) and sodium tripolyphosphate(TPP). The effects of CS content on complex microparticles and different ions, pH on the degree of equilibrium swelling were investigated. The component, structure and morphology of the complex microparticles were characterized by means of X-ray diffraction(XRD), Fourier transform infrared spectroscopy(FTIR), scanning electron microscopy(SEM). The results indicate that the CS-PVA is a compatible system; the crystallization of PVA declines with the increase of CS content; the particle size is about 400～950 μm with rough surfaces. The equilibrium swelling tests show that with the increase of CS content, the equilibrium swelling ratio increases firstly then decreases. The CS/PVA/TPP complex microparticles show highest equilibrium swelling ratio in a pH 3～8 solution and tend to decrease with the increase of ion content in the same aqueous solution. The microparticles have swelling-shrinking reversibility, implying that CS/PVA/TPP complex microparticles are pH/ion-sensitive and could provide experimental and theoretical basis for drug delivery system.
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