采用乳化交联法制备了可附载放射性核素的磁靶向药物载体--磁性壳聚糖微球,磁性微球中的纳米磁性Fe3O4粒子由FeSO4和FeCl3通过碱溶液的共沉淀法制备而得,借助SEM、IR及激光粒度仪等对微球的粒径、粒径分布和形貌进行了表征.结果表明:在壳聚糖溶液质量分数为1.5%,Fe3O4与壳聚糖的质量比为1∶2,悬浮介质的搅拌速度为1 200r/min等条件下制得的磁性壳聚糖微球的粒径在(40±20)μm,且呈规则的球形,可满足放射性核素载体的基本要求.
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