采用凝胶成型法制备用作骨移植和药物传递的多孔羟基磷灰石(HA)生物医用陶瓷,通过改变工艺参数制得了孔隙率和孔径可控、内部连通的三维网状开孔结构的HA,对其孔隙率、孔径及生物相容性进行了分析.结果表明:通过改变循环浸渍次数可以控制调节孔隙率在45%~92%之间;通过改变母体模板和浆料涂层的厚度可以控制孔径;制得的HA具有良好的生物相容性,具有这种特点的孔洞结构有利于骨细胞的生长.
参考文献
[1] | 姚秀敏,谭寿洪,江东亮.孔径可控的多孔羟基磷灰石的制备工艺研究[J].功能材料与器件学报,2001(02):152-156. |
[2] | 朱新文,江东亮,谭寿洪.碳化硅网眼多孔陶瓷的制备[J].无机材料学报,2000(06):1055-1060. |
[3] | Weng WJ.;Zhang S.;Cheng K.;Qu HB.;Du PY.;Shen G.;Yuan J.;Han GR. .Sol-gel preparation of bioactive apatite films[J].Surface & Coatings Technology,2003(2/3):292-296. |
[4] | Ghorbani M;Ehsani N.Some important factors in the wet preipitation process of hydroxyapatite[J].Materical and Design,2003(24):197-202. |
[5] | Anee TK.;Ashok M.;Palanichamy M.;Kalkura SN. .A novel technique to synthesize hydroxyapatite at low temperature[J].Materials Chemistry and Physics,2003(3):725-730. |
[6] | Pens J;Vallet-Regi M.Hydroxyapatite,tricalcium phosophate and biphasic matericals prepared by a liquid mix technique[J].Journal of the European Ceramic Society,2003(23):1687-1697. |
[7] | J. Pena;M. Vallet-Regi .Hydroxyapatite, tricalcium phosphate and biphasic materials prepared by a liquid mix technique[J].Journal of the European Ceramic Society,2003(10):1687-1696. |
[8] | Vacanti C;Vacanti J .Bone and cartilage reconstruction with tissue engineering approaches[J].Otolaryngologic Clinics of North America,1994,27:263-276. |
[9] | Vacanti,CA;Bonassar,LJ .An overview of tissue engineered bone.[J].Clinical Orthopaedics and Related Research,1999(367 Suppl):375-381. |
[10] | Burg KJ;Porter S;Kellam JF .Biomaterial developments for bone tissue engineering.[J].Biomaterials,2000(23):2347-2359. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分:
-
10%
-
20%
-
30%
-
40%
-
50%