利用金(Ⅰ)配合物催化吲哚与丙炔酸乙酯的Friedel-Crafts反应,探讨了最优化的实验条件,并合成了不同结构的β-取代双吲哚丙炔酸乙酯衍生物.通过氢谱、碳谱,对产物进行了表征.确定了新型反应--吲哚与丙炔酸乙酯在金催化下的亲电加成反应,并对反应机理进行了推测.
参考文献
| [1] | 马宇春,石峰,邓友全.金催化剂及其在有机反应中的应用研究进展[J].化学进展,2003(05):385-392. |
| [2] | 柯博文 .1.吲哚类生物碱Spirtryprostatin B的全合成研究 2.双吲哚甲烷类化合物制备方法学研究[D].四川大学,2005. |
| [3] | 柯博文 .1.吲哚类生物碱Spirtryprostatin B的全合成研究 2.双吲哚甲烷类化合物制备方法学研究[D].四川大学,2005. |
| [4] | Bond G C .Gold:a relatively new catalyst[J].Catalysis Today,2002,72:5-9. |
| [5] | Humphrey G R;Kuethe T .Practical Methodologies for the synthesis of indoles[J].Chemical Reviews,2006,106:2 875-2 911. |
| [6] | Li Z G;Shi Z J;He C .Addition of heterocycles to electron deficient olefins and alkynes catalyzed by gold(Ⅲ)[J].Journal of Organic Chemistry,2005,690:5 049-5 054. |
| [7] | Hiroyuki Kusama;Yuichi Miyashita;Jun Takaya;Nobuharu Iwasawa .Pt(Ⅱ)- or Au(Ⅲ)-Catalyzed [3+2] Cycloaddition of Metal-Containing Azomethine Ylides: Highly Efficient Synthesis of the Mitosene Skeleton[J].Organic letters,2006(2):289-292. |
| [8] | Nair V J;Vidya N;Abhilash K G .Gold(Ⅲ) chloride promoted addition of electron-rich heteroaromatic compounds to the C=C andC=Obonds of enals[J].Tetrahedron Letters,2006,47:2 871-2 873. |
| [9] | Mertins K;Lovel I;Kischel J;Zapf A;Beller M .Gold-catallyzed benzylation of arenes and heteroarenes[J].Advanced synthesis & catalysis,2006(6):691-695. |
| [10] | Bandgar B P;Shaikh K A .Molecular iodine-catalyzed efficient and highly rapid synthesis of bis(indolyl)methanes under mild conditions[J].Tetrahedron Letters,2003,44:1 959-1 961. |
| [11] | Stephen A;Hashmi K;Carmen Blanco M et al.Gold catalysis:first applications of cationic binuclear gold(Ⅰ)complexes and the first intermolecular reaction of an alkyne with a furan[J].Advanced Synthesis and Catalysis,2006,348:709-713. |
| [12] | Feuerstein M;Doucet H;Santelli M .Sonogashira reaction of heteroaryl halides with alkynes catalysed by a palladium-tetraphosphine complex[J].Journal of molecular catalysis, A. Chemical,2006(1/2):75-84. |
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