骨水泥自固化修饰聚氨酯多孔支架

硅酸盐通报 , 2006, 25(5): 83-86. doi: 10.3969/j.issn.1001-1625.2006.05.019

骨水泥自固化修饰聚氨酯多孔支架

周彩楼 ^1, , 蔡舒 ^2, , 肖张莹 ^3, , 赵丹 ^4, , 王彦伟 ^5,

1.天津城市建设学院材料科学与工程系,天津,300384

2.天津大学先进陶瓷与加工技术教育部重点实验室,天津,300072

3.天津大学先进陶瓷与加工技术教育部重点实验室,天津,300072

4.天津城市建设学院材料科学与工程系,天津,300384

5.天津大学先进陶瓷与加工技术教育部重点实验室,天津,300072

基金项目: 天津市自然科学基金(yfjmjc02900)

关键词：磷酸钙骨水泥 , 自固化 , 表面修饰

Surface Modification of Porous Polyurethane Scaffold by "Self-setting" of Calcium Phosphate Bone Cement

为了改善有机多孔支架的生物活性,利用磷酸钙骨水泥在潮湿空气中的自固化特性,以α-磷酸钙骨水泥为浆料体系,采用涂覆法对多孔聚氨酯进行表面修饰,获得了表面被羟基磷灰石(Cai0(PO4)6(OH)2,HAp)修饰层包裹的多孔复合材料.结果表明:在α-磷酸钙骨水泥浆料中加入2.5%(质量分数)的聚丙烯酸铵,通过与水化中成核的羟基磷灰石相互作用,改变表面电荷,能有效抑制羟基磷灰石的生长;水化后的修饰层主要由原位生长的纳米HAp晶须和多孔构成,晶须直径约为10～30nm;多孔体结构与模板相似,为贯通式通孔,孔径范围在150～500μm之间.通过自固化修饰技术,在保持原有材料的孔结构基础上,可有效改善其生物活性.

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