已经应用于临床的骨修复材料主要是生物活性陶瓷和金属如钛及其合金制成的生物材料,它们能与生物骨结合但与人体松质骨相比弹性模量高且柔韧性较低.需要研究一种具有与天然生物骨相类似力学性能的生物活性材料.目前已通过溶胶-凝胶法分别用PDMS、明胶、MPS及PTMO与无机系统合成了生物活性的有机-无机杂化材料,材料通过在有机基体中引入Ca2+和特殊的功能化基团如Si-OH等获得生物活性.其今后主要发展方向在于有机成分的引入以达到最佳的柔韧性和力学强度以及作用机理的研究以提高生物活性.
参考文献
| [1] | 朱振安,毛远青.骨科生物医用材料[J].生物骨科材料与临床研究,2005(03):21-23,28. |
| [2] | Hench L L;Splinter R J;Allen W C.Bonding mechanism at Interface of ceramic prosthetic materials[J].Journal of Biomedical Materials Research,1971(02):117-157. |
| [3] | Kokubo T;Kim HM;Kawashita M .Novel bioactive materials with different mechanical properties.[J].Biomaterials,2003(13):2161-2175. |
| [4] | 宁青菊,曹升福,王一峰,梁兰凤.生物活性玻璃陶瓷的制备及强度影响因素分析[J].陶瓷科学与艺术,2004(02):19-21. |
| [5] | KANJI TSURU;SATOSHI HAYAKAWA;AKIYOSHI OSAKA .Synthesis of Bioactive and Porous Organic-Inorganic Hybrids for Biomedical Applications[J].Journal of Sol-Gel Science and Technology,2004(1/3):201-205. |
| [6] | 庄菲.日本国生物医学材料[J].中国医疗器械杂志,2005(03):234. |
| [7] | Yan W Q;Nakamura T;Kobayashi M.Bonding of chemically treated titanium implants to bone[J].Journal of Biomedical Materials Research,1997(37):267-275. |
| [8] | 陈晓峰 .溶胶-凝胶生物活性材料的研制及其生物矿化性能研究[D].华南理工大学,2003. |
| [9] | Miyazaki T;Ohtsuki C;Tanihara M .Synthesis of bioactive organic-inorganic nanohybrid for bone repair through sol-Gel processing[J].Journal of Nanoscience and Nanotechnology,2003,3(06):511-515. |
| [10] | Qi Chen;Noboru Miyata;Tadashi Kokubo .Bioactivity and Mechanical Properties of Poly(dimethylsiloxane)-Modified Calcia-Silica Hybrids with Added Titania[J].Journal of the American Ceramic Society,2003(5):806-810. |
| [11] | Ogoshi T;Chujo Y .Organic-inorganic polymer hybrids prepared by the sol-gel method[J].Composite interfaces,2005(8/9):539-566. |
| [12] | Mark J E.Some general trends in the area of organic-Inorganic composites[J].hybrid organic-Inorganic composites,1995:1-3. |
| [13] | 黄剑锋.溶胶-凝胶原理与技术[M].北京:化学工业出版社,2005:181-214. |
| [14] | Mackenzie J D.Hybrid Organic-Inorganic Materials[A].,1995:226-236. |
| [15] | 李东风 .溶胶-凝胶法制备SiO<,2>体系有机-无机复合材料的研究[D].吉林大学,2000. |
| [16] | V.Bounor-Legare;C.Angelloz;P.Blanc;P.Cassagnau;A.Michel .A new route for organic-inorganic hybrid material synthesis through reactive processing without solvent[J].Polymer: The International Journal for the Science and Technology of Polymers,2004(5):1485-1493. |
| [17] | Zhitomirsky I;Niewczas M;Petric A.Electrodeposition of hybrid organic-inorganic films containing iron oxide[J].Materials Letters,2003(57):1045-1050. |
| [18] | Ohtsuki C;Miyazaki T;Tanihara M.Development of bioactive organic-inorganic hybrid for bone substitutes[J].Materials Science and Engineering C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS,2002(22):27-34. |
| [19] | 尾坂明義.ゾル-ゲル法の生体(適合)材料開発への応用[J].Ceramics Japan Bulletin of the Ceramic Society of Japan,2004(03):205-209. |
| [20] | Q.Chen;M.Kamitakahara;N.Miyata;T.Kokubo;T.Nakamura .Preparation of Bioactive PDMS-Modified CaO-SiO_2-TiO_2 Hybrids by the Sol-Gel Method[J].Journal of Sol-Gel Science and Technology,2000(1/3):101-105. |
| [21] | M.Kamitakahara;M. Kawashita;N. Miyata .Bioactivity and Mechanical Properties of Polydimethylsiloxane (PDMS)-CaO-SiO_2 Hybrids with Different PDMS Contents[J].Journal of Sol-Gel Science and Technology,2001(1/2):75-81. |
| [22] | Akira Ito;Atsunori Mase;Yohei Takizawa;Masashige Shinkai;Hiroyuki Honda;Takeshi Kobayashi;Ken-Ichiro Hata;Minoru Ueda .Transglutaminase-Mediated Gelatin Matrices Incorporating Cell Adhesion Factors as a Biomaterial for Tissue Engineering[J].Journal of Bioscience and Bioengineering,2003(2):196-199. |
| [23] | Ren L;Tsuru K;Hayakawa S.Synthesis and characterization of gelatin-siloxane hybrids derived through sol-gel procedure[J].Journal of Sol-Gel Technology,2001(21):115-121. |
| [24] | Miyata N;Fuke K;Chen Q.Bioactivity and mechanical behavior of PTMO-modified CaO-SiO2 hybrids prepared by sol-gel process[A].Trans Tech Publications,Switzerland,2000:681-684. |
| [25] | Miyata N;Fuke K;Chen Q;Kawashita M;Kokubo T;Nakamura T .Apatite-forming ability and mechanical properties of PTMO-modified CaO-SiO2 hybrids prepared by sol-gel processing: effect of CaO and PTMO contents.[J].Biomaterials,2002(14):3033-3040. |
| [26] | C.Ohtsuki;T.Miyazaki;M.Tanihara .Synthesis of Bioactive Organic-Inorganic Hybrid from Methacryloxypropyltrimethoxysilane and 2-Hydroxyethylmethacrylate[J].Key engineering materials,2001(192/195):39-42. |
| [27] | Yabuta T;Tsuru K;Hayakawa S.Synthesis of bioactive organic-Inorganic hybrids with γ-methacryloxypropyltrimethoxysilane[J].Journal of Sol-Gel Technology,2000(19):745-748. |
| [28] | Kokubo T;Kushtani H;Sakka S.Solution Able to reproduce In-vivo surfacestructure changes in bioactive glass-ceramic A-W[J].Journal of Biomedical Materials Research,1990(24):721-755. |
| [29] | Ren L;Tsuru K;Hayakawa S;Symposuim CC.In vitro apatite deposition and biodegradation of porous gelatin-silicate hybrids[J].Hybrid Organic /Inorganic Materials,2000(04):24-28. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%