组织工程支架材料在组织工程中正发挥着越来越重要的作用.组织工程的核心是构建细胞生物支架材料复合体,其中,三维多孔支架材料发挥着重大作用.除了决定新生组织、器官的形状外,最重要的是为细胞提供获取营养、气体交换、废物排除的环境,为细胞增殖繁衍提供空间.因此,支架材料应是高度多孔的,支架的孔隙大小必须控制,并有严格要求.本文主要介绍了骨组织三维多孔材料的研究现状,并对组织工程支架及骨修复过程做了简要的介绍,并对其发展方向作了展望.
参考文献
| [1] | 孙宁宁,王绪凯.骨组织工程支架材料的研究进展[J].国际生物医学工程杂志,2007(04):251-254. |
| [2] | 邓迟,翁杰,周绍兵,卢雄,汪建新,冯波,屈树新,李孝红.羟基磷灰石表面吸附性能的研究综述[J].材料导报,2007(09):84-87. |
| [3] | 罗德福,赵康,苏波,吴少旭.球形多孔羟基磷灰石支架的孔结构特征与力学性能[J].硅酸盐学报,2007(09):1205-1209. |
| [4] | 陈清宇,翁杰.纳米羟基磷灰石/聚乳酸复合材料力学性能[J].化工新型材料,2007(10):80-81. |
| [5] | 王辉,赵云山,张西正,雷鹏森,郝鹤.聚乳酸类支架材料研究进展[J].医疗卫生装备,2003(11):25-27. |
| [6] | 马爱洁,杨青芳,梁威,祖恩峰,薛丹.生物可降解多孔支架的研究进展[J].材料科学与工程学报,2005(05):621-624. |
| [7] | 许建中.骨组织工程的研究与开发进展[J].第三军医大学学报,2005(16):1625-1627. |
| [8] | G.A.Silva;P.Ducheyne;R.L Reis .Materials in particulate form for tissue engineering,1.Basic concepts[J].Journal of Tissue Eng Regen Med,2007,1:4-24. |
| [9] | G.A.Silva;O.P.Coutinho;P.Ducheyne;R.L.Reis .Materials in particulate form for tissue engineering,2.Applications in bone[J].Journal of Tissue Eng Regen Med,2007,1:97-109. |
| [10] | Jun Jin Yoon;Tae Gwan Park .Degradation behaviors of biodegradable macroporous scaffolds prepared by gas foaming of effervescent salts[J].Journal of biomedical materials research, Part B. Applied biomaterials,2001(3):401-408. |
| [11] | Park T G .Pedusion culture of hepatocytes within galactose derivatized biodegradable POl scaffolds prepared by gas foaming of effervescent salts[J].Journal of Biomedical Materials Research,2002,59(01):127-135. |
| [12] | Mooney DT.;Breuer C.;Mcnamara K.;Hern D.;Vacanti JP. Langer R.;Mazzoni CL. .STABILIZED POLYGLYCOLIC ACID FIBRE BASED TUBES FOR TISSUE ENGINEERING[J].Biomaterials,1996(2):115-124. |
| [13] | Guoping Chen;Takashi Ushida;Tetsuya Tateishi .Development of biodegradable porous scaffolds for tissue engineering[J].Materials science & engineering, C. Biomimetic and supramolecular systems,2001(1/2):63-69. |
| [14] | Whang K.;Healy KE.;Nuber G.;Thomas CH. .A NOVEL METHOD TO FABRICATE BIOABSORBABLE SCAFFOLDS[J].Polymer: The International Journal for the Science and Technology of Polymers,1995(4):837-842. |
| [15] | Nam YS;Yoon JJ;Park TG .A novel fabrication method of macroporous biodegradable polymer scaffolds using gas foaming salt as a porogen additive.[J].Journal of biomedical materials research, Part B. Applied biomaterials,2000(1):1-7. |
| [16] | Yu X;Botchwey EA;Levine EM;Pollack SR;Laurencin CT .Bioreactor-based bone tissue engineering: The influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization.[J].Proceedings of the National Academy of Sciences of the United States of America,2004(31):11203-11208. |
| [17] | Zeltinger J;Sherwood JK;Graham DA;Mueller R;Griffith LG .Effect of pore size and void fraction on cellular adhesion, proliferation, and matrix deposition.[J].Tissue engineering,2001(5):557-572. |
| [18] | Sikavitsas VI;Temenoff JS;Mikos AG .Biomaterials and bone mechanotransduction.[J].Biomaterials,2001(19):2581-2593. |
| [19] | Silva GA;Costa FJ et al.Entrapment ability and release profile of corticosteroids from starch-based particles[J].Journal of Biomedical Materials Research,2005,73A(02):234-243. |
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