以戊二醛为交联剂,硝酸铈铵为引发剂,在壳聚糖(CS)/聚乙烯基吡咯烷酮(PVP)二元凝胶的基础上,通过引入聚乙烯醇(PVA),制备了具有温度和pH双重敏感性的CS基三元智能水凝胶.结果表明,PVA的引入可显著提高CS在体系中的用量,增加凝胶的温度敏感级数,增强敏感度.在PVA用量为6.25％(相对于PVP的质量分数,下同),0.4％交联剂,5.1％引发剂,80℃下反应6h的条件下,可获得最大溶胀率约为1500％的三元凝胶.CS基三元凝胶在实验考察的温度范围内具有四级温度敏感性,且在35℃附近有一显著敏感点；对不同的pH值具有较好的敏感性,敏感突变点在pH=2附近.
参考文献
| [1] | Zhou, Y.;Ma, G.;Shi, S.;Yang, D.;Nie, J. .Photopolymerized water-soluble chitosan-based hydrogel as potential use in tissue engineering[J].International Journal of Biological Macromolecules: Structure, Function and Interactions,2011(3):408-413. |
| [2] | BHATTARAI N;GUNN J;ZHANG M Q .Chitosan-based hydrogels for controlled,localized drug delivery[J].Advanced Drug Delivery Reviews,2010,62(01):83-99. |
| [3] | Yian Zheng;Dajian Huang;Aiqin Wang .Chitosan-g-poly( acrylic acid) hydrogel with crosslinked polymeric networks for Ni~(2+) recovery[J].Analytica chimica acta,2011(2):193-200. |
| [4] | Vaghani SS;Patel MM .Hydrogels based on interpenetrating network of chitosan and polyvinyl pyrrolidone for pH-sensitive delivery of repaglinide.[J].Current drug discovery technologies,2011(2):126-135. |
| [5] | Vaghani SS;Patel MM .pH-sensitive hydrogels based on semi-interpenetrating network (semi-IPN) of chitosan and polyvinyl pyrrolidone for clarithromycin release.[J].Drug development and industrial pharmacy,2011(10):1160-1169. |
| [6] | 易国斌,康正,杨少华,崔亦华.PVP/CHI交联共混水凝胶的pH敏感性研究[J].化学研究与应用,2006(10):1175-1178. |
| [7] | DERGUNOV S A;MUN G A .γ-irradiated chitosan-polyvinyl pyrrolidone hydrogels as pH-sensitive protein delivery system[J].Radiation Physics and Chemistry,2009,78(01):65-68. |
| [8] | 易国斌,康正,崔亦华,郭建维,杨少华.温度敏感性PVP/CHI共混水凝胶的制备与溶胀性能[J].化学与生物工程,2006(05):20-22. |
| [9] | Jagjit R.Khurma;David R.Rohindra;Ashveen V.Nand .Swelling and Thermal Characteristics of Genipin Crosslinked Chitosan and Poly(vinyl pyrrolidone)Hydrogels[J].Polymer bulletin,2005(3):195-204. |
| [10] | Yan Li;Yumin Du;Yufeng Tang .A novel pH-sensitive and freeze-thawed carboxymethyl chitosan/poly(vinyl alcohol) blended hydrogel for protein delivery[J].Polymer international,2009(10):1120-1125. |
| [11] | 陈欢欢,昝佳,林莹,蒋国强,丁富新.壳聚糖/聚乙烯醇温敏水凝胶的制备及性质研究[J].清华大学学报（自然科学版）,2006(06):843-846. |
| [12] | 舒静,李小静,赵大飙,冯晓荟,郑丽娜.温度/pH敏感性壳聚糖-聚乙烯吡咯烷酮水凝胶的制备[J].高分子材料科学与工程,2011(08):150-153. |
| [13] | Dai W.S.;Barbari T.A. .Hydrogel membranes with mesh size asymmetry based on the gradient crosslinking of poly(vinyl alcohol)[J].Journal of Membrane Science,1999(1):67-79. |
| [14] | Jagjit R.Khurma;Ashveen V.Nand .Temperature and pH sensitive hydrogels composed of chitosan and poly(ethylene glycol)[J].Polymer bulletin,2008(6):805-812. |
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