用试管倒置法研究在甘油磷酸钠存在下,壳聚糖-明胶体系的温敏凝胶化性能.体系3组分的体积比V(壳聚糖)∶V(G)∶V(甘油磷酸钠)从10∶0.5∶1～10∶0.5∶2.5(体系pH值6.8),37℃下凝胶化时间由(1200±60)s降至150s;V(壳聚糖)∶V(G)∶V(甘油磷酸钠)体积比从10∶0.25∶2～10∶1.25∶2(体系pH值6.8),37℃下凝胶化时间从(300±10)s增至(690±30)s.固定三者体积配比,明胶浓度增大,37℃下凝胶化时间延长.pH值在6.8～7.2范围适合于体系凝胶化.调节体积配比及合适的pH值,可实现壳聚糖/明胶/甘油磷酸钠体系在37℃下快速凝胶化.以布洛芬为模型药物,24h载药温敏凝胶累积释放度为(79.28±2.0)％,而24h布洛芬原药累积释放度为(97.04±2.5)％,表明载药凝胶对药物具有缓释作用.
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