一种新型医用高氮无镍不锈钢的生物相容性研究

功能材料, 2013, 44(16): 2362-2366. doi: 10.3969/j.issn.1001-9731.2013.16.016

一种新型医用高氮无镍不锈钢的生物相容性研究

王文革 ^1, , 邹兴政 ^2, , 王宏 ^3, , 李方 ^4, , 张十庆 ^5, , 丁渝红 ^6, , 王东哲 ^7,

1.海装重庆局,重庆400033

2.重庆材料研究院,重庆400707

3.重庆材料研究院,重庆400707

4.重庆材料研究院,重庆400707

5.重庆材料研究院,重庆400707

6.重庆材料研究院,重庆400707

7.重庆材料研究院,重庆400707

基金项目: 重庆市科技计划攻关资助项目(CSTC2010AB5116)

关键词：高氮无镍不锈钢 , 生物相容性 , 细胞粘附 , 细胞毒性

Biocompatibility study of a new type of medical high nitrogen nickel-free stainless

WANG Wen-ge ^1, , ZOU Xing-zheng ^2, , WANG Hong ^3, , LI Fang ^4, , ZHANG Shi-qing ^5, , DING Yu-hong ^6, , WANG Dong-zhe ^7,

1.海装重庆局,重庆400033

2.重庆材料研究院,重庆400707

3.重庆材料研究院,重庆400707

4.重庆材料研究院,重庆400707

5.重庆材料研究院,重庆400707

6.重庆材料研究院,重庆400707

7.重庆材料研究院,重庆400707

Keywords： high nitrogen nickel-free stainless steel , biocompatibility , cell adhesion , cell toxicity

研究了成骨细胞及血小板在不同氮含量的新型高氮无镍奥氏体不锈钢材料表面的粘附及细胞毒性表现.通过血小板粘附实验考察不同氮含量的高氮无镍奥氏体不锈钢材料的血液相容性;通过MTT实验和细胞粘附实验考察不同氮含量的高氮无镍奥氏体不锈钢材料的细胞相容性.结果表明,不同氮含量的高氮无镍奥氏体不锈钢材料对血小板粘附的影响不显著;不同氮含量的无镍不锈钢材料对成骨细胞的生长、形态和增殖不构成伤害,且氮含量对细胞的粘附影响并不显著;细胞毒性实验表明,高氮无镍奥氏体不锈钢和对照组钛合金材料性能稳定,对成骨细胞的生长没有产生明显的毒副作用.

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