由于具有优异的力学相容性、生物相容性和可降解性，镁及其合金成为新一代生物医用可降解金属植入材料的研究焦点。但镁及其合金由于较快的降解速率，严重制约了其在临床上的应用步伐。开发高强度、高韧性、高耐蚀，且降解行为可控的高性能镁合金迫在眉睫。综述了生物医用可降解镁合金的最新研究进展，详细介绍了镁及其合金作为生物医用材料的优势与不足、产品研发现状、降解机理及腐蚀行为和耐蚀性研究，并指出了研究中存在的问题和未来发展方向。
Due to the excellent mechanical compatibility,biocompatibility and biodegradability,magnesium and its alloys are becoming the research focus of a new generation of biomedical degradable metallic implant materi-als.However,the rapid degradation rate of magnesium and its alloys puts serious obstacles in the way of their clinical applications.It is highly urgent to develop magnesium alloys with high strength,high toughness,high corrosion resistance,and controllable degradation behavior.The latest research progress in degradable biomed-ical magnesium alloys was reviewed.The advantages and disadvantages,current products,degradation mecha-nism and corrosion behavior,and corrosion resistance research were presented in detail for magnesium and its alloys as biomedical materials.The problems in the research and future development directions were also point-ed out.
参考文献
| [1] | Witte F;Kaese V;Haferkamp H;Switzer E;Meyer Lindenberg A;Wirth CJ;Windhagen H .In vivo corrosion of four magnesium alloys and the associated bone response.[J].Biomaterials,2005(17):3557-3563. |
| [2] | Guangling Song .Control of biodegradation of biocompatable magnesium alloys[J].Corrosion Science: The Journal on Environmental Degradation of Materials and its Control,2007(4):1696-1701. |
| [3] | Assessing the corrosion of biodegradable magnesium implants: A critical review of current methodologies and their limitations[J].Acta biomaterialia,2012(3):925-936. |
| [4] | Gu X;Zheng Y;Cheng Y;Zhong S;Xi T .In vitro corrosion and biocompatibility of binary magnesium alloys.[J].Biomaterials,2009(4):484-498. |
| [5] | 张海晓,陈福南,王韶音,刘芳,张鹏.镁合金表面水热一步法制备生物膜层及其表征[J].功能材料,2012(13):1730-1732. |
| [6] | 高家诚,胡德,宋长江.医用镁合金降解及其对人体的影响[J].功能材料,2012(19):2577-2583. |
| [7] | Okuma T .Magnesium and bone strength[J].NUTRITION,2001,17(7/8):679-680. |
| [8] | Vormann J .Magnesium: nutrition and metabolism.[J].Molecular Aspects of Medicine: An Interdisciplinary Review Journal,2003(1/3):27-37. |
| [9] | Staiger MP;Pietak AM;Huadmai J;Dias G .Magnesium and its alloys as orthopedic biomaterials: A review[J].Biomaterials,2006(9):1728-1734. |
| [10] | Erinc M;Sillekens W H;Mannens G.Applicabil-ity of existing magnesium alloys as biomedical implant materials[A].New York,2009:209-214. |
| [11] | 洪岩松,杨柯,张广道,黄晶晶,郝玉全,艾红军.可降解镁合金的动物体内骨诱导作用[J].金属学报,2008(09):1035-1041. |
| [12] | 袁青领,阎钧,郑起.可降解镁合金材料的研究新进展[J].材料导报,2010(05):132-135. |
| [13] | Bin Wang;Shaokang Guan;Jun Wang .Effects of Nd on microstructures and properties of extruded Mg-2Zn-0.46Y-xNd alloys for stent application[J].Materials Science & Engineering, B. Solid-State Materials for Advanced Technology,2011(20):1673-1678. |
| [14] | Sternberg K;Gratz M;Koeck K;Mostertz J;Begunk R;Loebler M;Semmling B;Seidlitz A;Hildebrandt P;Homuth G;Grabow N;Tuemmler C;Weitschies W;Schmitz KP;Kroemer HK .Magnesium used in bioabsorbable stents controls smooth muscle cell proliferation and stimulates endothelial cells in vitro.[J].Journal of biomedical materials research, Part B. Applied biomaterials,2012(1):41-50. |
| [15] | 耿芳,谭丽丽,张炳春,郑丰,杨柯.多孔镁作为新型骨组织工程材料的研究探索[J].材料导报,2007(05):76-78,85. |
| [16] | Witte F;Ulrich H;Rudert M;Willbold E .Biodegradable magnesium scaffolds: Part 1: appropriate inflammatory response.[J].Journal of biomedical materials research, Part A,2007(3):748-756. |
| [17] | Witte F;Ulrich H;Palm C;Willbold E .Biodegradable magnesium scaffolds: Part II: peri-implant bone remodeling.[J].Journal of biomedical materials research, Part A,2007(3):757-765. |
| [18] | C.E. Wen;Y. Yamada;K. Shimojima .Compressibility of porous magnesium foam: dependency on porosity and pore size[J].Materials Letters,2004(3/4):357-360. |
| [19] | Lili Tan;Mingming Gong;Feng Zheng;Bingchun Zhang;Ke Yang .Study on compression behavior of porous magnesium used as bone tissue engineering scaffolds[J].Biomedical materials,2009(1):015016-1-015016-7-0. |
| [20] | Geng Fang;Tan Lili;Zhang Bingchun et al.Study on beta-TCP coated porous Mg as a bone tissue engineering scaffold material[J].Journal of Materials Science &Technology,2009,25(01):123-129. |
| [21] | 宋光铃.镁合金腐蚀与防护[M].北京:化学工业出版社,2006:75-83. |
| [22] | 张汉茹,郝远.AZ91D镁合金在含Cl-溶液中腐蚀机理的研究[J].铸造设备研究,2007(03):19-23,27. |
| [23] | Shaw B A.ASM handbook volume 13a:corrosion:fun-damentals,testing and protection[M].USA:ASM In-ternational,2003:692-696. |
| [24] | B. A. O. McCormack;C. D. Walsh;S. P. Wilson;P. J. Prendergast .A statistical analysis of microcrack accumulation in PMMA under fatigue loading: applications to orthopaedic implant fixation[J].International Journal of Fatigue,1998(8):581-592. |
| [25] | Gu XN;Zhou WR;Zheng YF;Cheng Y;Wei SC;Zhong SP;Xi TF;Chen LJ .Corrosion fatigue behaviors of two biomedical Mg alloys - AZ91D and WE43 - In simulated body fluid.[J].Acta biomaterialia,2010(12):4605-4613. |
| [26] | Choudhary,L.;SinghRaman,R.K. .Magnesium alloys as body implants: Fracture mechanism under dynamic and static loadings in a physiological environment[J].Acta biomaterialia,2012(2):916-923. |
| [27] | Witte F;Fischer J;Nellesen J;Crostack HA;Kaese V;Pisch A;Beckmann F;Windhagen H .In vitro and in vivo corrosion measurements of magnesium alloys[J].Biomaterials,2006(7):1013-1018. |
| [28] | Chenglong Liu;Yunchang Xin;Xiubo Tian .Degradation susceptibility of surgical magnesium alloy in artificial biological fluid containing albumin[J].Journal of Materials Research,2007(7):1806-1814. |
| [29] | Levesque J;Hermawan H;Dube D;Mantovani D .Design of a pseudo-physiological test bench specific to the development of biodegradable metallic biomaterials.[J].Acta biomaterialia,2008(2):284-295. |
| [30] | 刘通,张永君.医用镁合金降解控制技术的研究进展[J].材料导报,2010(21):86-89,100. |
| [31] | 任伊宾,黄晶晶,杨柯,张炳春,姚治铭,王浩.纯镁的生物腐蚀研究[J].金属学报,2005(11):1228-1232. |
| [32] | Kannan MB;Raman RKS .In vitro degradation and mechanical integrity of calcium-containing magnesium alloys in modified-simulated body fluid[J].Biomaterials,2008(15):2306-2314. |
| [33] | YIN Dong-song,ZHANG Er-lin,ZENG Song-yan.Effect of Zn on mechanical property and corrosion property of extruded Mg-Zn-Mn alloy[J].中国有色金属学会会刊（英文版）,2008(04):763-768. |
| [34] | Zhang, EL;Yin, DS;Xu, LP;Yang, L;Yang, K .Microstructure, mechanical and corrosion properties and biocompatibility of Mg-Zn-Mn alloys for biomedical application[J].Materials science & engineering, C. Biomimetic and supramolecular systems,2009(3):987-993. |
| [35] | Erlin Zhang;Lei Yang .Microstructure, mechanical properties and bio-corrosion properties of Mg–Zn–Mn–Ca alloy for biomedical application[J].Materials Science & Engineering, A. Structural Materials: Properties, Misrostructure and Processing,2008(1/2):111-118. |
| [36] | Xiaobo Zhang;Guangyin Yuan;Lin Mao;Jialin Niu;Wenjiang Ding .Biocorrosion properties of as-extruded Mg-Nd-Zn-Zr alloy compared with commercial AZ31 and WE43 alloys[J].Materials Letters,2012(1):209-211. |
| [37] | Hornberger,H.;Virtanen,S.;Boccaccini,A.R. .Biomedical coatings on magnesium alloys - A review[J].Acta biomaterialia,2012(7):2442-2455. |
| [38] | Yizao Wan;Guangyao Xiong;Honglin Luo;Fang He;Yuan Huang;Xiaoshong Zhou .Preparation and characterization of a new biomedical magnesium-calcium alloy[J].Materials & design,2008(10):2034-2037. |
| [39] | Zeng Rongchang;Dietzel W;Chen Jun et al.Corrosion behavior of TiO2 coating on magnesium alloy AM60 in Hank's solution[J].Key Engineering Materials,2008,373/374:609-612. |
| [40] | Y.W. Song;D.Y. Shan;E.H. Han .Electrodeposition of hydroxyapatite coating on AZ91D magnesium alloy for biomaterial application[J].Materials Letters,2008(17/18):3276-3279. |
| [41] | 高亚丽,熊党生,王存山,潘学民.医用镁合金激光熔覆羟基磷灰石涂层初探[J].特种铸造及有色合金,2009(04):305-307. |
| [42] | Yang, JX;Jiao, YP;Cui, FZ;Lee, IS;Yin, QS;Zhang, Y .Modification of degradation behavior of magnesium alloy by IBAD coating of calcium phosphate[J].Surface & Coatings Technology,2008(22/23):5733-5736. |
| [43] | 曾荣昌,孔令鸿,陈君,崔洪芝,刘成龙.医用镁合金表面改性研究进展[J].中国有色金属学报,2011(01):35-43. |
| [44] | Chen, Y.;Song, Y.;Zhang, S.;Li, J.;Zhao, C.;Zhang, X. .Interaction between a high purity magnesium surface and PCL and PLA coatings during dynamic degradation[J].Biomedical materials,2011(2):025005-1-025005-8. |
| [45] | Gu, XN;Zheng, YF;Lan, QX;Cheng, Y;Zhang, ZX;Xi, TF;Zhang, DY .Surface modification of an Mg-1Ca alloy to slow down its biocorrosion by chitosan[J].Biomedical materials,2009(4):044109:1-044109:4. |
| [46] | Zhang XP;Zhao ZP;Wu FM;Wang YL;Wu J .Corrosion and wear resistance of AZ91D magnesium alloy with and without microarc oxidation coating in Hank's solution[J].Journal of Materials Science,2007(20):8523-8528. |
| [47] | Witte F;Fischer J;Nellesen J;Vogt C;Vogt J;Donath T;Beckmann F .In vivo corrosion and corrosion protection of magnesium alloy LAE442.[J].Acta biomaterialia,2010(5):1792-1799. |
| [48] | Frank Wittea;Norbert Hort;Carla VOgt;Smadar Cohen;Karl Ulrich Kainer;Regine Willumeit;Frank Feyerabend .Degradable biomaterials based on magnesium corrosion[J].Current opinion in solid state & materials science,2008(5/6):63-72. |
| [49] | Jian-Wei Chang;Xing-Wu Guo;Peng-Huai Fu;Li-Ming Peng;Wen-Jiang Ding .Effect of heat treatment on corrosion and electrochemical behaviour of Mg-3Nd-0.2Zn-0.4Zr (wt.%) alloy[J].Electrochimica Acta,2007(9):3160-3167. |
| [50] | Xiaobo Zhang;Guangyin Yuan;Lin Mao;Jialin Niu;Penghuai Fu;Wenjiang Ding.Effects of extrusion and heat treatment on the mechanical properties and biocorrosion behaviors of a Mg-Nd-Zn-Zr alloy.[J].Journal of the mechanical behavior of biomedical materials,2012:77-86. |
| [51] | Li Z;Gu X;Lou S;Zheng Y .The development of binary Mg-Ca alloys for use as biodegradable materials within bone.[J].Biomaterials,2008(10):1329-1344. |
| [52] | Microstructure and corrosion properties of as sub-rapid solidification Mg-Zn-Y-Nd alloy in dynamic simulated body fluid for vascular stent application[J].Journal of Materials Science. Materials in Medicine,2010(7):2001-2008. |
| [53] | Liao, J.;Hotta, M.;Mori, Y..Improved corrosion resistance of a high-strength Mg-Al-Mn-Ca magnesium alloy made by rapid solidification powder metallurgy[J].Materials Science & Engineering, A. Structural Materials: Properties, Misrostructure and Processing,2012:10-20. |
| [54] | Bruno Zberg;Peter J. Uggowitzer;Jorg F. Loffler .MgZnCa glasses without clinically observable hydrogen evolution for biodegradable implants[J].Nature materials,2009(11):887-891. |
| [55] | Witte F;Feyerabend F;Maier P;Fischer J;Stormer M;Blawert C;Dietzel W;Hort N .Biodegradable magnesium-hydroxyapatite metal matrix composites.[J].Biomaterials,2007(13):2163-2174. |
| [56] | D.-B. Liu;Y. Huang;P.B. Prangnell.Microstructure and performance of a biodegradable Mg-1Ca-2Zn-1TCP composite fabricated by combined solidification and deformation processing[J].Materials Letters,2012:7-9. |
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