以自制的琥珀酰化壳聚糖(SUCS)和羟甲基-5-氟尿嘧啶(5-FuOH)为原料,制备了壳聚糖偶联载药体(SUCS-5-FuOH)。傅里叶红外光谱(FT-IR)、核磁共振(1 H-NMR )、热重(TG )和 X 粉末衍射(XRD)等技术表征了产物的化学结构、热稳定性和结晶行为。并通过紫外光谱(UV )分析了产物对5-FuOH 的接枝率及其体外释药行为。结果表明,SUCS和5-FuOH 间通过酯键化学键合,接枝率(载药率)为18.7%,在模拟体液和酶存在条件下均有良好的缓释性能。
Chitosan coupling drug-loading body (SUCS-5-FuOH)was prepared with homemade succinyl-chi-tosan (SUCS)and hydroxymethyl-5-fluorouracil (5-FuOH)as materials.The chemical structure,thermal sta-bility and crystallization behavior of the obtained sample were characterized by Fourier infrared spectrum (FT-IR),nuclear magnetic resonance (1 H-NMR),thermal gravimetric analysis (TG)and X-ray powder diffraction (XRD).The grafting rate of 5-FuOH and the in vitro releasing performance were analysed by UV spectrum (UV).The results indicated that SUCS and 5-FuOH were chemically bonded through ester linkage,the graft-ing rate (drug loading rate)of SUCS-5-FuOH was 18.7%,and it had good sustained-release performance under the condition of simulated body fluids and enzymes.
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