通过稳态荧光探针法、激光光散射法等研究了苄氧基封端的甲基丙烯酸-2-(二甲氨基)乙酯和甲基丙烯酸甲酯的两亲性嵌段聚合物 BzO-PDMAE-MA30-PMMA10在水溶液中的胶束化行为。实验结果表明该共聚物具有明显的 pH 值和温度响应性。使用憎水性药物萘普生和亲水性药物维生素 C,制备胶束-药物体系,采用紫外分光光度法考查该体系在药物控制释放方面的应用。体外释放实验表明药物释放体系随pH 值降低可以加快药物释放,温度升高而致使释放变快。药物释放体系无突释现象,且具有 pH 值和温度响应性。
The micellization behavior of the diblock copolymer BzO-PDMAEMA30-b-PMMA10 in aqueous solution were investigated by the measurements of fluorescence probe techniques and laser light scattering studies.Using naproxen as model hydrophobic drugs and using vitamin C as model hydrophilic drugs,the application of amphiphilic polymer on controlled-release drug delivery systems were investigated by UV-visible spectrophotometer. The results demonstrated that the release rate of naproxen from polymer micelles were significantly faster drug release by reducing of pH values.Furthermore,the release rate run faster by increasing of temperature. Any initial burst release was not observed in the experiments.The drug-controlled release showed pH-responsive and thermoresponsive.
参考文献
| [1] | 陈卫星,范晓东,刘郁杨.星形两亲性嵌段共聚物的自组装及其药物控释行为研究[J].功能材料,2008(04):663-666. |
| [2] | 罗亚莉,姚新建,袁金芳,高青雨.聚离子复合物胶束的制备及其对辅酶A的控制释放[J].功能材料,2009(05):840-842,845. |
| [3] | 赵群,倪沛红.PH/温度响应的两亲性嵌段共聚物的研究[J].化学进展,2006(06):768-779. |
| [4] | Ma Y H;Tang Y Q;Billingham N C et al.Synthesis of biocompatible,stimuli-responsive,physical gels based on ABA triblock copolymers[J].Biomacromolecules,2003,4:864-868. |
| [5] | M.Licciardi;Y.Tang;N.C.Billingham;S.P.Armes;A.L.Lewis .Synthesis of Novel Folic Acid-Functionalized Biocompatible Block Copolymers by Atom Transfer Radical Polymerization for Gene Delivery and Encapsulation of Hydrophobic Drugs[J].Biomacromolecules,2005(2):1085-1096. |
| [6] | Banez MVD.;Butun V.;Armes SP.;Robinson KL. .Use of oxyanion-initiated polymerization for the synthesis of amine methacrylate-based homopolymers and block copolymers[J].Polymer: The International Journal for the Science and Technology of Polymers,2001(1):29-37. |
| [7] | Shiyoung Liu;Steven P.Armes .Polymeric Surfactants for the New Millenium: A pH-Responsive, Zwitterionic, Schizophrenic Diblock Copolymer[J].Angewandte Chemie International Edition,2002(8):1413-1416. |
| [8] | Liu SY.;Armes SP. .Synthesis and aqueous solution behavior of a pH-responsive schizophrenic diblock copolymer[J].Langmuir: The ACS Journal of Surfaces and Colloids,2003(10):4432-4438. |
| [9] | Zhao Q;Ni PH .Synthesis of well-defined and near narrow-distribution diblock copolymers comprising PMMA and PDMAEMA via oxyanion-initiated polymerization[J].Polymer: The International Journal for the Science and Technology of Polymers,2005(9):3141-3148. |
| [10] | Qiongqiong Liu;Zhangqing Yu;Peilong Ni .Micellization and applications of narrow-distribution poly[2-(dimethylamino)ethyl methacrylate][J].Colloid and polymer science,2004(4):387-393. |
| [11] | Mao J;Ni PH;Mai YY;Yan DY .Multicompartment micelles from hyperbranched star-block copolymers containing polycations and fluoropolymer segment[J].Langmuir: The ACS Journal of Surfaces and Colloids,2007(9):5127-5134. |
| [12] | Liu, CC;He, JL;Zhao, Q;Zhang, MZ;Ni, PH .Well-Defined Poly[(dimethylamimo)ethyl methacrylate]-b-Poly(fluoroalkyl methacrylate) Diblock Copolymers: Effects of Different Fluoroalkyl Groups on the Solution Properties[J].Journal of Polymer Science, Part A. Polymer Chemistry,2009(10):2702-2712. |
| [13] | Huai-chao Wang,Ming-zu Zhang,Pei-hong Ni,Jin-lin He,Ying Hao,Yi-xian Wu.SYNTHESIS OF pH-RESPONSIVE AMPHIPHILIC DIBLOCK COPOLYMERS CONTAINING POLYISOBUTYLENE via OXYANION-INITIATED POLYMERIZATION AND THEIR MULTIPLE SELF-ASSEMBLY MORPHOLOGIES[J].高分子科学（英文版）,2013(02):218-231. |
| [14] | 袁媛,张明祖,张虎,倪沛红.pH响应性含氟三嵌段共聚物的制备及性质研究[J].化学学报,2010(15):1537-1544. |
| [15] | 李玉萍 .温敏性接枝共聚物胶束载药体系的研究[D].浙江大学,2004. |
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