采用LiCl/DMAc的溶解体系将细菌纤维素溶解后制备再生细菌纤维素(RBC)膜,并研究了成膜的细菌纤维素溶液浓度对膜的结晶度、平衡含水率、透光率以及对营养物质(氯化钠、葡萄糖、色氨酸)的透过性能的影响.实验结果表明,随着成膜溶液浓度的升高,再生膜的结晶度有一定程度的降低；平衡含水率稍有升高；再生膜干态下的透光率变化不大,但浸泡PBS后膜变化较大；对营养物质的透过系数随浓度变化较小,对葡萄糖和色氨酸的透过系数相近,约为1．0×10-6 cm2/s,氯化钠的透过率系数约为2．5×10-6 cm2/s.研究表明再生细菌纤维素膜是一种潜在的人工角膜板层移植材料.
In this work,regenerated bacterial cellulose (RBC)membrane was prepared by LiCl/DMAc,and in-fluence of the concentration of bacterial cellulose solution on crystallinity,equilibrium water content,light transmittance and the diffusion of nutrients (sodium chloride,glucose sugar,tryptophan)of RBC membrane were studied.The experimental results showed that,with the concentration of bacterial cellulose solution in-creasing,the degree of crystallinity of regenerated membrane slightly decreased;equilibrium water content in-creased slightly and light transmittance of dry films changed little,but that of wet films changed obviously;the diffusion coefficient to nutrients hardly changed with the BC solution concentration,and that to glucose sugar and tryptophan were approximately 1.0 × 10-6 cm2/s,and the sodium chloride permeability coefficient was about 2.5×10-6 cm2/s.This work indicated that RBC membrane was promising biomaterial for corneal lamellar transplantation application.
参考文献
| [1] | Iguchi M;Yamanaka S;Budhiono A .Bacterial cellu-lose-a masterpiece of nature's arts[J].Journal of Materials Science,2000,35:161-270. |
| [2] | 郝常明,罗祎.细菌纤维素--一种新兴的生物材料[J].纤维素科学与技术,2002(02):56-61. |
| [3] | Wojciech K.Czaja;David J.Young;Marek Kawecki .The Future Prospects of Microbial Cellulose in Biomedical Applications[J].Biomacromolecules,2007(26):1-12. |
| [4] | Serafica G;Weinberger L .Porous structures of microbial-derived cellulose for in bivo implantation[P].US:A1,20100158985,2010-7-24. |
| [5] | Lima, G.D.M.;Sierakowski, M.-R.;Faria-Tischer, P.C.S.;Tischer, C.A. .Characterisation of bacterial cellulose partly acetylated by dimethylacetamide/lithium chloride[J].Materials science & engineering, C. Biomimetic and supramolecular systems,2011(2):190-197. |
| [6] | Kadokawa JI;Murakami MA;Kaneko Y .A facile preparation of gel materials from a solution of cellulose in ionic liquid[J].Carbohydrate research,2008(4):769-772. |
| [7] | Quanling Yang;Haisong Qi;Ang Lue .Role of sodium zincate on cellulose dissolution in NaOH/urea aqueous solution at low temperature[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2011(3):1185-1191. |
| [8] | 王敏,朱平,赵晓霞,董朝红.细菌纤维素在LiCl/DMAc溶剂体系中的溶解性能研究[J].合成纤维,2008(06):20-23. |
| [9] | 王家鸣,任力,龙玉宇,刘卅,王迎军,季培红,林明楷,席蕾.壳聚糖-胶原复合膜渗透性能的研究[J].功能材料,2012(20):2747-2750. |
| [10] | Gao Shanshan;Wang Jianqing;Jin Zhengwei .Preparation of cellulose films from solution of bacterial cellulose in NMMO[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2012(2):1020-1025. |
| [11] | O'Connor R T;Dupre E F;Mitcham D .Applications of infrared absorption spectroscopy to investigations of cot-ton and modified cottons part I:physical and crystalline modifications and oxidation[J].Textile Research Journal,1958,28:382-392. |
| [12] | 陈嘉翔.制浆化学[M].北京:中国轻工业出版社,1990:21. |
| [13] | Qiuying Gao;Xinyuan Shen;Xinkun Lu .Regenerated bacterial cellulose fibers prepared by the NMMO·H2O process[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2011(3):1253-1256. |
| [14] | Phisalaphong M;Suwanmajo T;Sangtherapitiku P .Novel nanoporous membranes from regenerated bacterial cellulose[J].Journal of Applied Polymer Science,2008(1):292-299. |
| [15] | Wang Yingjun;Guo Li;Ren Li et al.A study on the performance of hyaluronic acid immobilized chitosan film[J].Biomedical Materials,2009,4:035009. |
| [16] | 何曼君;陈维孝;张红东.高分子物理(第三版)[M].上海:复旦大学出版社,2008:186. |
| [17] | 蔡立彬,刘正堂,崔英德,黎新明,张延霖,韩慧芳.共聚物水凝胶角膜接触镜材料的离子渗透性研究[J].材料导报,2006(12):134-136. |
| [18] | Liu W;Merrett K;Griffith M;Fagerholm P;Dravida S;Heyne B;Scaiano JC;Watsky MA;Shinozaki N;Lagali N;Munger R;Li F .Recombinant human collagen for tissue engineered corneal substitutes.[J].Biomaterials,2008(9):1147-1158. |
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