采用同晶置换以 Zn2+代替 Mg2+合成 Mg/Zn/Al-LDHs,并将茶碱插入 LDHs 层间形成超分子复合物。通过 XRD、FT-IR、UV 和 TG-DTA 考察了Mg/Zn/Al-LDHs 和茶碱插层组装 Mg/Zn/Al-LDHs的反应条件及影响因素。结果表明,采用共沉淀法,在n(Mg)∶n(Zn)∶n(Al)∶n(茶碱)=3∶1∶1∶2、p H值=9、T=80℃、晶化12 h的条件下可获得化学组成清晰和结晶度良好的无机/有机杂化型药物插层LDHs。测试了茶碱插层 LDHs 在不同介质中的缓释性能,及其茶碱的释放量,探讨了茶碱插层LD H s的缓释机理。
Mg/Zn/Al-LDHs were prepared by isomorphous substitution with Zn2+ instead of Mg2+,forming su-pramolecular composites by inserting theophylline into LDHs layer.The reaction conditions and influence fac-tors of Mg/Zn/Al-LDH and intercalated-LDHs were studied by XRD,FT-IR,UV and TG-DTA.The inorgan-ic/organic heterozygous drug intercalated-LDHs of clear chemical composition and good crystallinity were ob-tained by coprecipitation method at best condition(n(Mg)∶n(Zn)∶n(Al)=3∶1∶1∶2,pH=9,T=80 ℃, and crystallization time of 12 h).Sustained-release properties of theophylline-intercalated LDHs and calculated release quantity of theophylline were tested,and controlled-release mechanism of the theophylline-intercalated LDH was discussed.
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