利用磁性纳米粒子在交变磁场作用下的磁热效应，来实现对 Fe3 O4/P(NIPAAm-co-Am)复合微球温度的控制，以达到肿瘤热疗与化疗联合治疗的目的。主要研究了交变磁场作用下复合微球的磁热性能的影响因素。研究结果表明，所制备的 Fe3 O4/P (NIPAAm-co-Am)复合微球具有很好的超顺磁性，且在交变磁场作用下具有很好的磁热效应，其磁热效应可以通过调节微球的浓度、交变磁场的磁场强度和频率等因素来调控，以适应不同应用场合需求。
Research on the magnetic thermo-sensitive composite microspheres for controlled release drug carrier was meaningful.Magnetocaloric effect was used to heat the Fe3O4/P (NIPAAm-co-Am)composite micro-spheres,and the heat generation abilities of the composited microspheres in alternation magnetic field (AMF) were investigated in the present work.Results show the resultant Fe3O4/P(NIPAAm-co-Am)composite mi-crospheres exhibite excellent superparamagnetic and high heating generation ability.The temperature of the composite microspheres was raised after exposed to AMF,which can stimulate the shrinks of P(NIPAAm-co-Am).Furthermore,the temperature raised after exposed to AMF can be adj usted by controlling the concentra-tion of composite microspheres,the magnetic intensity and the frequency of the AMF.
参考文献
| [1] | Soyeon Kim;Kevin E.Healy .Synthesis and characterization of injectable poly(N-isopropylacrylamide-co-acrylic acid) hydrogels with proteolytically degradable cross-links[J].Biomacromolecules,2003(5):1214-1223. |
| [2] | Klouda L;Mikos AG .Thermoresponsive hydrogels in biomedical applications.[J].European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V,2008(1):34-45. |
| [3] | Gao Zheng-guo;Cui Yuan;Tao Xiangdong .Synthesis and thermo-responsiv property of end-functionalized poly(N-isopropylacrylamide)with two saccharide group[J].Journal of Functional Materials,2012,43:133-136. |
| [4] | 隋静,胡娜,施冬健,尚跃再,陈明清.PDEAm接枝PAN/PSt温敏性聚合物微球的制备及表征[J].功能材料,2012(01):133-136. |
| [5] | Ankareddi I;Brazel CS .Synthesis and characterization of grafted thermosensitive hydrogels for heating activated controlled release.[J].International Journal of Pharmaceutics,2007(2):241-247. |
| [6] | Purushotham S;Ramanujan RV .Thermoresponsive magnetic composite nanomaterials for multimodal cancer therapy.[J].Acta biomaterialia,2010(2):502-510. |
| [7] | Zhang J;Misra RD .Magnetic drug-targeting carrier encapsulated with thermosensitive smart polymer: core-shell nanoparticle carrier and drug release response.[J].Acta biomaterialia,2007(6):838-850. |
| [8] | Müller S .Magnetic fluid hyperthermia therapy for malig-nant brain tumors-an ethical discussion[J].Nanomedi-cine:NBM,2009,5:387-393. |
| [9] | Issels RD .Hyperthermia adds to chemotherapy.[J].European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR),2008(17):2546-2554. |
| [10] | Zhang JL;Srivastava RS;Misra RDK .Core-shell magnetite nanoparticles surface encapsulated with smart stimuli-responsive polymer: Synthesis, characterization, and LCST of viable drug-targeting delivery system[J].Langmuir: The ACS Journal of Surfaces and Colloids,2007(11):6342-6351. |
| [11] | Hirotake Wakamatsu;Kazuya Yamamoto;Aiko Nakao .Preparation and characterization of temperature-responsive magnetite nanoparticles conjugated with N-isopropylacrylamide-based functional copolymer[J].Journal of Magnetism and Magnetic Materials,2006(2):327-333. |
| [12] | 艾凡荣,姚爱华,黄文旵,王德平.磁场-温度双重响应性复合微球的制备与表征[J].高等学校化学学报,2010(09):1701-1705. |
| [13] | Le J;Isobe T;Senna M J .Synthesis of biocompatible poly [2-(methacryloyloxy)ethyl phosphorylcholine]-coated magnetite nanoparticles[J].Colloid Interf Sci,1996,177:490-494. |
- 下载量()
- 访问量()
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%