利用简洁、环保、绿色的方法合成金属纳米粒子对于扩展纳米粒子在生物化学及组织工程中的应用具有重大意义。利用高碘酸钠对壳聚糖进行氧化反应制备双醛壳聚糖(D-CTS),用FT-IR、元素分析法对D-CTS进行表征,将制得的D-CTS作为还原剂和稳定剂制备纳米银粒子,最后用UV-Vis、DLS、FT-IR、XRD、SEM对制备的纳米银粒子进行表征。结果表明,D-CTS的氧化度和反应液的pH值对纳米粒子的粒径分布及微观结构有重要影响。D-CTS中的醛基和氨基是稳定纳米银粒子的主要基团。XRD分析制得的纳米银具有较好面心立体晶体结构,所制备的纳米银粒子粒径在30~40nm之间,同时常温条件下具有较好稳定性。
The increasing awareness regarding green chemistry had prompted the need for an eco-friendly ap-proach to synthesize nanoparticles that was simple,cost-effective,and compatible with biomedical and pharma-ceutical applications.A simple,green method was developed for the synthesis of silver nanoparticles (AgNPs) by using dialdehyde chitosan (D-CTS)as the reducing and stabilizing agents.D-CTS was prepared from the oxi-dation of chitosan by sodium periodate,and its degree of oxidation was determined by elemental analysis and Fourier-transform infrared spectroscopy (FT-IR).The synthesized AgNPs were characterized by UV-Vis spec-troscopy,dynamic light scattering (DLS),FT-IR,X-ray diffraction (XRD)and scanning electron microscopy (SEM).The results indicated that the morphology and size distribution of the AgNPs were found to vary with the dialdehyde content of D-CTS and the pH value of the reaction solution.The aldehyde groups and the amino groups were the major agents that stabilized the AgNPs.XRD results indicated the presence of nano-silver with face-centered cubic structure.SEM results showed that nano-silver particles of 30-40 nm in size were homogene-ously dispersed in the solution.Meantime,the synthesized AgNPs remained stable in normal condition.
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