壳聚糖温敏水凝胶是一种非化学交联智能水凝胶，其成胶性能取决于凝胶组分，形成特定的质-构关系。温和的制备条件和良好的生物活性，使壳聚糖水凝胶在组织工程、药物缓释，特别是细胞培养、液态栓塞剂等领域的研究应用取得了新进展。综述了壳聚糖温敏水凝胶的分类、成胶性能、相变机制及其在生物医药领域研究和应用的新进展。
Chitosan based thermosensitive hydrogel was a type of intelligent gel that was nonchemical-crosslinked,whose structures are closely correlated with specific ingredients.Its mild preparation,desirable bioactivity and biocompatibility make it broadly applied in tissue engineering and drug controlled release.Nota-bly,its applications as fluid embolizing agent and cell culture matrix for ready harvest have attracted numerous attentions recently.This review intends to summarize its categorization,gelling behavior,mode of gelation and novel applications.
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