壳聚糖具有良好的生物降解性、生物相容性、抗菌性等优异性能,受到研究者们的广泛关注.在前期研究的基础上,将卤胺改性壳聚糖(CTS-GH)与聚乙烯醇(PVA)进行物理混合,制备不同比例的复合膜,以提高卤胺改性壳聚糖膜的实际应用价值.利用原子力显微镜(AFM)考察了两者在溶液中的混合性质；采用扫描电镜(SEM)、示差扫描量热仪(DSC)、X射线衍射(XRD)对复合膜进行了表征；测试了经过氯化处理后复合膜的抗菌性能.结果表明,除 CTS-GH/PVA＝10/90外,均能得到混合性能良好的复合膜.经过氯化处理后,氯含量为0．86×1018个原子/cm2(CTS-GH/PVA＝20/80)的复合膜可在5 min内杀死98．92％金黄色葡萄球菌和100％大肠杆菌,60 min 接触后可杀死100％金黄色葡萄球菌.
Chitosan has attracted researchers'wide attention due to its excellent properties such as biodegrad-ability,biocompatibility and antibacterial property.Based on our preliminary studies,composite films in differ-ent proportions were prepared by physically mixing N-halamine modified chitosan (CTS-GH)and polyvinyl al-cohol (PVA)to improve practical application of composite films.The miscibility of the mixed solution was ex-amined by atomic force microscopy (AFM).The miscibility of the composite films was characterized by scan-ning electron microscopy (SEM),differential scanning calorimetry (DSC),X-ray diffraction (XRD).The anti-microbial property of the chlorinated composite film was evaluated.The results showed that the miscibility of CTS-GH/PVA composite film is perfect with the exception of CTS-GH/PVA=10/90.After the chlorination treatment,the composite film with chlorine content of 0.86×1018 atoms/cm2 (CTS-GH/PVA=20/80)can kill 98.92% Staphylococcus aureus and 100% Escherichia coli within 5 min,and 100% Staphylococcus aureus with-in 60 min.
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