以消炎镇痛药(S)-布洛芬与 Cu2＋配合物为模板分子，以甲基丙烯酸为功能单体，乙二醇二甲基丙烯酸酯为交联剂，聚砜膜为多孔支撑层，利用辐射引发聚合制备了 Cu2＋配位分子印迹复合膜。通过紫外光谱研究发现，(S)-布洛芬、Cu2＋和甲基丙烯酸形成了配位比为1∶2∶2的3元配合物。通过扫描电镜及渗透实验发现聚砜基膜固含量为17％时，修饰后印迹膜形态及性能最好。同时，通过选择渗透实验发现，印迹膜对其手性对称物(R)-布洛芬及结构类似物酮洛芬渗透选择性较差。
Using (S)-ibuprofen-Cu2+ complex as template,methacrylic acid as the functional monomer,ethylene glycol dimethacrylate (EGDMA)as the cross-linker and poly-sulfone membrane as the porous support layer, (S)-ibuprofen-Cu2+ metal-complexing imprinted polymer membrane were prepared via radiation polymerization. Through the UV-Vis spectrum study,(S)-ibuprofen,Cu2+ and methyl acrylic acid were formed ternary com-plexes with the ratio 2∶1∶2.By scanning electron microscopy (SEM)and permeation experiment,when the solid content of poly-sulfone membrane was 1 7%,the morphology and performance of imprinted membrane were the best after modification.At the same time,by selective permeation experiment,it was found that com-pared to its chiral symmetry compound (R)-ibuprofen and structural analogues ketoprofen,the imprinted mem-brane only showed excellent permeability to (S)-ibuprofen.
参考文献
| [1] | 苏杰,尹晓斐.分子印迹聚合物及其应用[J].山东理工大学学报（自然科学版）,2008(06):90-95. |
| [2] | Tan Tianwei.Molecular imprinting technology and appli-cation[M].北京:化学工业出版社,2010 |
| [3] | Cheong, W.J.;Yang, S.H.;Ali, F. .Molecular imprinted polymers for separation science: A review of reviews (Review)[J].Journal of separation science,2013(3):609-628. |
| [4] | 管萍,胡小玲,郝明燕.红霉素分子印迹膜的制备及性能研究[J].功能材料,2010(z2):379-382. |
| [5] | Ma Xiangxia;Li Wenyou;He Xiwen et al.Permeation characteristics of cobalt(Ⅱ)-complex molecularly im-printed polymer membranes[J].Acta Chimica Sinaca,2005,63:1682-1685. |
| [6] | 李昱琢,李辉,逯翠梅,李贵,李志平,符再德.尼古丁印迹材料的制备表征及对烟气中尼古丁的吸附研究[J].功能材料,2013(09):1289-1293. |
| [7] | Fan Peimin;Wang Bing .Preparation of quercetin's met-al-complexing imprinted polymer membrane and its prop-erties[J].Acta Chimica Sinaca,2010,68:2543-2550. |
| [8] | Lian, H.;Hu, Y.;Li, G..Novel metal ion-mediated complex imprinted membrane for selective recognition and direct determination of naproxen in pharmaceuticals by solid surface fluorescence[J].Talanta: The International Journal of Pure and Applied Analytical Chemistry,2013:460-467. |
| [9] | 赵广超,石勇,肇启东,李新勇,李春艳,薛方红.基于纳米金膜的双酚A分子印迹传感器研究[J].功能材料,2014(01):1099-1103. |
| [10] | 谢武,汤又文,刘燕英,左雄军,李核,徐志广.S-布洛芬印迹聚合物微球的制备及应用[J].分析测试学报,2008(12):1293-1297. |
| [11] | Liu Jing;Wang bing .Precipitate preparation of chloram-phenicol molecularly imprinted nanospheres by electron beam radiation[J].Polymer Materials Science and Engi-neering,2014,30:143-148. |
| [12] | Xie Guiquan;Yang Wenqing .The synthesis and charac-terization of the brufen coordination compounds of some 3d transition metals[J].Journal of Jinan University,1988,1:101-105. |
| [13] | Cristina Nunez;Adrian Fernandez-Lodeiro;Javier Fernandez-Lodeiro.Synthesis, spectroscopic studies and in vitro antibacterial activity of Ibuprofen and its derived metal complexes[J].Inorganic Chemistry Communications,2014:61-65. |
| [14] | Should Yan;Zhixian Gao;Yanjun Fang .Characterization and quality assessment of binding properties of malachite green molecularly imprinted polymers prepared by precipitation polymerization in acetonitrile[J].Dyes and Pigments,2007(3):572-577. |
- 下载量()
- 访问量()
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%