采用熔融共混制备了5种聚乳酸(PDL-LA)/聚己内酯(PCL)共混医用材料,并进行挤出流延制备薄片.采用原子力显微镜研究薄片的表面形貌和截面高度曲线,与纯 PDLLA 相比,共混物的表面相对光滑、截面高度曲线振幅减小,最高凸起从800 nm 下降到180 nm 以下.PCL 的加入提高了共混物的表面平整度,获得更加光滑的外观,原因在于分子量相对较小的 PCL 产生润滑和增塑效应所致.PCL 含量为30％时共混物的柔性较好、半衰期为90 d,与肌腱手术的临床要求相匹配,适合用于制备肌腱吻合器.细胞培养实验表明,成纤细胞在 PDLLA/PCL(70/30)共混物薄片表面的数量很少,说明其不容易粘附在材料表面,具有较好的防粘连作用.
5 kinds of poly laitic acid (PDLLA)/polycaprolactone (PCL)blends for medical use were prepared by melt process,and the films were prepared by extrusion casting.The surface morphology and section height curve of these films were studied by atomic force microscopy (AFM).Compared with the pure PDLLA,the surface of PDLLA/PCL blends is relatively smooth,the section height curve amplitude decreases,the highest bulges decreased from 800nm down to 180nm below.The addition of PCL could improve the surface flatness of the blends,obtained more smooth appearance,which was caused by lubricating and PDLLA sticizing effect of PCL with the lower molecular weight.The blends with 30% PCL content had a good flexibility and a half-life of 90 d,which was matched with the clinical requirement of tendon operation,and suited for the preparation of tendon stapler.In cell culture experiments,the number of fibroblast cells in the surface of blend mat of PDL-LA/PCL (70/30)were very few,which showed that the cell was not easy adhesion to the surface of the materi-al.The material had good function of preventing adhesion.
参考文献
| [1] | Gisha E. Luckachan;C. K. S. Pillai .Biodegradable Polymers- A Review on Recent Trends and Emerging Perspectives[J].Journal of polymers and the environment,2011(3):637-676. |
| [2] | Yang Fanwen;Chen Xiaoming .Study onrheological prop-erties of medical grade PLLA and PDLA[J].Synthetic Material Aging and Application,2012,41(06):6-8. |
| [3] | John M. Onyari;Francis Mulaa;Joshua Muia;Paul Shiundu .Biodegradability of Poly (lactic acid), Preparation and Characterization of PLA/Gum Arabic Blends[J].Journal of polymers and the environment,2008(3):205. |
| [4] | Gou-Jen Wang;Kuan-Hsuan Ho;Cheng-Chih Hsueh .Biodegradable polylactic acid microstructures for scaffold applications[J].Microsystem technologies,2008(7):989-993. |
| [5] | Yang Fanwen;Chen Xiaoming;Zhu Jixiang et al.Self-reinforced and biomimetic materials and it’s preparation[P].China Patent,20130059977.6,2013-07-17. |
| [6] | Yang Fanwen;Lin Yongliang;Tian Xiumei et al.Prepa-ration of PDLLA/PCL blend and its application on medi-cal materials[J].Engineering Plastics Application,2014,42(02):1-5. |
| [7] | Yang Fanwen;Chen Xiaoming .Material and preparation of tendon anastomosis[P].China Patent,201210246728.3,2012-10-24. |
| [8] | Yang Fanwen;Chen Xiaoming;Peng Ye et al.A boot mold used for preparing self-reinforced biomimetic mate-rials[P].China Patent,201320086957.3,2013-2-26. |
| [9] | Yang Fanwen;Chen Xiaoming;Huang Xinyue et al.A self-locking mechanism tendon stapler with biological ab-sorption properties[P].China Patent,201320008240.7,2013-01-08. |
| [10] | Nadia Ljungberg;Bengt Wesslen .Tributyl citrate oligomers as plasticizers for poly(lactic acid):thermo-mechanical film properties and aging[J].Polymer: The International Journal for the Science and Technology of Polymers,2003(25):7679-7688. |
| [11] | 肖淼,杨其,蔡盛梅,程小莲,李光宪.PCL增韧PLA共混材料的制备与性能研究[J].塑料工业,2010(06):15-18. |
| [12] | Vozzi G.;Flaim C.;Ahluwalia A.;Bhatia S. .Fabrication of PLGA scaffolds using soft lithography and microsyringe deposition[J].Biomaterials,2003(14):2533-2540. |
- 下载量()
- 访问量()
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%