利用自制的可聚合阳离子乳化剂甲基丙烯酰氧乙基二甲基十六烷基溴化铵(MDHB),与甲基丙烯酸甲酯(MMA)通过胶束共聚合得到阳离子的纳米聚合物.测定了聚合产物的粒径、zeta 电位和分子量,用 FT-IR、1 H NMR 和 TG 对产物结构进行表征,用二倍稀释法研究了该类聚合物对大肠杆菌(E．coli)和金黄色葡萄球菌(S．aureus)的最低杀菌浓度(MBC)和最低抑菌浓度(MIC).结果表明,MDHB 是影响聚合物的结构特征及抗菌性的主要因素,随着 MDHB 用量增加,粒径增大、抗菌性增强、zeta 电位和分子量降低.聚合产物热稳定性良好,能添加到通用聚合物中制得抗菌材料,因而该类聚合物有望成为具有开发应用潜力的新型抗菌剂.
Cationic nanopolymers were prepared by micellar copolymerization of methylmathacrylate (MMA) with methacryloxyethyldimethylhexadecyl ammonium bromide (MDHB).The particle size,zeta potential and molecular weight of the polymers were measured,and the structures were characterized by FT-IR,1 H NMR and TG.The minimum inhibitory concentration (MIC)and the minimum bactericidal concentration(MBC)of this kind of polymer against E.Coli and S.aureus were tested using a broth dilution test.The results shown that the concentration of MDHB plays a key role in structural characteristics and antibacterial properties of the products. With increasing of MDHB in recipe,particle size and antibacterial activity increase,zeta potential and molecular weight decrease.The polymers have good thermal stability,so they can be blended with common polymer ma-trix to prepare antibacterial materials.Therefore this kind of polymer is expected to be a promising antibacterial agent for development and application.
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