以乙二胺(EDA)、丙烯酸甲酯(MA)、聚乙二醇单甲醚-1900(mPEG-1900)、胱胺二盐酸盐为原料合成两亲树枝状大分子体系(mPEG-G4.0,mPEG-G(S-S)3.0,mPEG-G(S-S)4.0),通过傅里叶红外(FT-IR)确定聚合物的结构,以阿霉素(DOX)为模型分子研究该药物载体的包载和药物释放情况,获得树状大分子的特点、性质及对氧化还原的敏感性.结果表明mPEG-G4.0胶束、mPEG-G(S—S)3.0胶束、mPEG-G(S-S) 4.0胶束的粒径均在670 nm以下,且均具有良好的药物包载性能.载有DOX的mPEG-G(S-S)3.0,mPEG-G(S-S)4.0胶束在高的浓度GSH条件下药物释放速度较快,具有显著的氧化还原敏感性.
参考文献
| [1] | Wang,J.;Yang,G.;Guo,X.;Tang,Z.;Zhong,Z.;Zhou,S..Redox-responsive polyanhydride micelles for cancer therapy[J].Biomaterials,20149(9):3080-3090. |
| [2] | Yang Li;Tao Liu;Guoying Zhang;Zhishen Ge;Shiyong Liu.Tumor-Targeted Redox-Responsive Nonviral Gene Delivery Nanocarriers Based on Neutral-Cationic Brush Block Copolymers[J].Macromolecular rapid communications: Publishing the newsletters of the European Polymer Federation,20144(4):466-473. |
| [3] | 任龙芳;郭子东;王学川.PAMAM型树枝状水性聚氨酯的合成及表征?[J].功能材料,2015(1):1061-1065. |
| [4] | Krishna R. Raghupathi;Jing Guo;Oyuntuya Munkhbat.Supramolecular Disassembly of Facially Amphiphilic Dendrimer Assemblies in Response to Physical, Chemical, and Biological Stimuli[J].Accounts of Chemical Research,20147(7):2200-2211. |
| [5] | Sánchez-Nieves,J.;Fransen,P.;Pulido,D.;Lorente,R.;Mu?oz-Fernández,M.á.;Albericio,F.;Royo,M.;Gómez,R.;DeLaMata,F.J..Amphiphilic cationic carbosilane-peg dendrimers: Synthesis and applications in gene therapy[J].European Journal of Medicinal Chemistry: Chimie Therapeutique,2014:43-52. |
| [6] | Song, N.;Liu, W.;Tu, Q.;Liu, R.;Zhang, Y.;Wang, J..Preparation and in vitro properties of redox-responsive polymeric nanoparticles for paclitaxel delivery[J].Colloids and Surfaces, B. Biointerfaces,20112(2):454-463. |
| [7] | Yu, L.;Yao, L.;You, J.;Guo, Y.;Yang, L..Poly(methyl methacrylate)/poly(ethylene glycol)/poly(ethylene glycol dimethacrylate) micelles: Preparation, characterization, and application as doxorubicin carriers[J].Journal of Applied Polymer Science,20141(1):39623-1-39623-8. |
| [8] | Li,J.;Huo,M.;Wang,J.;Zhou,J.;Mohammad,J.M.;Zhang,Y.;Zhu,Q.;Waddad,A.Y.;Zhang,Q..Redox-sensitive micelles self-assembled from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxel[J].Biomaterials,20127(7):2310-2320. |
| [9] | Kang Wang;Guo-Feng Luo;Yun Liu.Redox-sensitive shell cross-linked PEG-polypeptide hybrid micelles for controlled drug release[J].Polymer chemistry,20124(4):1084-1090. |
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