采用共混和同轴静电纺制备了负载盐酸四环素药物的聚乙烯醇-苯乙烯吡啶盐(PVA-SbQ)/玉米醇溶蛋白(Zein)复合纳米纤维，在紫外光照射下得到光交联载药 PVA-SbQ/Zein 复合纳米纤维。利用扫描电镜(SEM)对不同纤维的形貌和直径分布进行了分析；采用透射电镜(TEM)对不同静电纺丝法制备的纳米纤维结构进行了观察和比较；强力测试表明同轴静电纺丝制备的纳米纤维力学性能更强；傅里叶变换红外光谱(FT-IR)曲线表明载药PVA-SbQ/Zein复合纳米纤维保持了原有的化学功能基团；最后比较了两种方法制备的载药纳米纤维膜的药物释放行为。
Drug tetracycline hydrochloride (TCH)-loaded PVA-SbQ/Zein composite nanofibers were fabricated by co-electrospinning and coaxial-electrospinning,respectively.Then the nanofibers were irradiated under UV light to get the cross-linked ones.The morphologies and diameter distributions of drug-loaded PVA-SbQ/Zein composite nanofibers were observed by SEM.TEM was used to compare the structure of the two kind of nanofi-bers.The strength test showed that the tensile strength of coaxial-electrospun nanofibers was better than the co-electrospun ones.The spectra of FT-IR indicated that composite nanofibers maintained their own original functional groups.Finally,the drug release behavior of drug-loaded nanofibers prepared with two methods was compared.
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