介绍了叶酸靶向载药微粒的特性及其作用机制，本节就叶酸靶向药物的高分子载体进行了简要综述。重点阐述了叶酸靶向药物微粒的不同聚合物载体以及制备方法。其中针对传统方法中存在的有机溶剂残留、粒径和形貌难控制等缺点，介绍了一种绿色有效的方法—超临界抗溶剂法(SAS)，并对该方法制备载药微粒的原理以及应用进行了简要概括。最后对超临界抗溶剂法制备新型叶酸-聚合物靶向载药微粒进行了展望。
The characteristics and principle on the folate-targeted drug particles are described briefly in this arti-cle.It is especially discussed that the different polymers as carrier and preparation methods of the folate-targeted drug loading particles.Aim at the questions of the residual organic solvents,particle size and morphology hard to control and so on in traditional methods,a green and efficient method,supercritical anti-solvent method (SAS)is put forward,and the principles and applications of the method are discussed.Finally new folate-poly-mer targeted drug loading microspheres that prepared by the supercritical CO2 anti-solvent method are prospec-ted.
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